PWP1 and NFYA

Data Source:
BioGRID (two hybrid)

		PWP1	NFYA
Description		PWP1 homolog, endonuclein	nuclear transcription factor Y subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Chromosome Nucleolus Golgi Apparatus	Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex
	Molecular Function	H4K20me3 Modified Histone Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Transcription, DNA-templated Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Histone H4-K20 Trimethylation Ribosome Biogenesis Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Differentiation	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways			PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		Acne (severe) ( 24927181)	Mean spheric corpuscular volume ( 32888494) White blood cell count ( 27863252)
Interacting Genes		5 interacting genes: APP DAPK1 HOXA3 NFYA SMURF1	48 interacting genes: APP APPBP2 ATF6 ATF6B ATXN1 BANP BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 DVL3 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 POU3F2 PWP1 QRICH1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 UBL5 USF1 USF2 VEZF1 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		11137	4800
HPRD ID		11464	01793
Ensembl ID		ENSG00000136045	ENSG00000001167
Uniprot IDs		A0A024RBH5 B4DJV5 Q13610	A0A024RD22 P23511
PDB IDs			4AWL 6QMP 6QMQ 6QMS
Enriched GO Terms of Interacting Partners?
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