HIBADH and CLEC2A

Data Source:
BioGRID (two hybrid)

		HIBADH	CLEC2A
Description		3-hydroxyisobutyrate dehydrogenase	C-type lectin domain family 2 member A
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GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding 3-hydroxyisobutyrate Dehydrogenase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor NADP Binding NAD Binding	Protein Binding Carbohydrate Binding Protein Homodimerization Activity
	Biological Process	Valine Catabolic Process Branched-chain Amino Acid Catabolic Process	Natural Killer Cell Mediated Cytotoxicity
Pathways		Branched-chain amino acid catabolism
Drugs		NADH
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Asthma ( 31959851) Diastolic blood pressure ( 27841878) General risk tolerance (MTAG) ( 30643258) Kidney stones ( 31729369) Lead levels in blood ( 25820613) Pulse pressure ( 27841878) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Systolic blood pressure ( 27841878)	Malaria ( 31844061)
Interacting Genes		39 interacting genes: ADAM33 AGTRAP AIG1 AMELY AQP3 ASGR1 BRCA1 C2CD2L CDS2 CLEC2A CMTM7 CNIH2 COMT CTSA EFNA5 ERMP1 GOSR2 MAL NDUFB11 PAEP PLN PRAF2 PTCH1 RTP2 SCARB2 SEC22B SFT2D2 SNORC TFRC TM6SF2 TMEM14B TMEM222 TMEM60 TMEM86B TRIM63 UBIAD1 VAMP2 VAMP5 ZFPL1	5 interacting genes: CLEC2D GPR37L1 GPX8 HIBADH TEX29
Entrez ID		11112	387836
HPRD ID		12238	16720
Ensembl ID		ENSG00000106049	ENSG00000188393
Uniprot IDs		A0A024RA75 P31937	Q6UVW9
PDB IDs		2GF2 2I9P	4IOP
Enriched GO Terms of Interacting Partners?
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