RBPMS and PSMF1

Data Source:
BioGRID (two hybrid)

		RBPMS	PSMF1
Description		RNA binding protein, mRNA processing factor	proteasome inhibitor subunit 1
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GO Annotations	Cellular Component	P-body Nucleoplasm Cytosol Cytoplasmic Stress Granule	Nucleoplasm Endoplasmic Reticulum Cytosol Proteasome Core Complex Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Transcription Coactivator Activity RNA Binding MRNA Binding Protein Binding Poly(A) Binding Protein Homodimerization Activity	Endopeptidase Inhibitor Activity Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Proteasome Binding
	Biological Process	RNA Processing Response To Oxidative Stress Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of SMAD Protein Signal Transduction	MAPK Cascade Protein Polyubiquitination Stimulatory C-type Lectin Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Amino Acid Metabolic Process Negative Regulation Of Endopeptidase Activity Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Protein Deubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Tumor Necrosis Factor-mediated Signaling Pathway NIK/NF-kappaB Signaling Fc-epsilon Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of MRNA Stability Post-translational Protein Modification T Cell Receptor Signaling Pathway Transmembrane Transport Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Interleukin-1-mediated Signaling Pathway Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Proteasomal Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Hematopoietic Stem Cell Differentiation
Pathways			Activation of NF-kappaB in B cells Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Vpu mediated degradation of CD4 Vif-mediated degradation of APOBEC3G SCF(Skp2)-mediated degradation of p27/p21 Degradation of beta-catenin by the destruction complex Downstream TCR signaling Regulation of activated PAK-2p34 by proteasome mediated degradation Separation of Sister Chromatids FCERI mediated NF-kB activation Autodegradation of the E3 ubiquitin ligase COP1 Regulation of ornithine decarboxylase (ODC) ABC-family proteins mediated transport AUF1 (hnRNP D0) binds and destabilizes mRNA Asymmetric localization of PCP proteins Degradation of AXIN Degradation of DVL Hedgehog ligand biogenesis Hh mutants are degraded by ERAD Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling Degradation of GLI1 by the proteasome Degradation of GLI2 by the proteasome GLI3 is processed to GLI3R by the proteasome Hedgehog 'on' state Regulation of RAS by GAPs TNFR2 non-canonical NF-kB pathway NIK-->noncanonical NF-kB signaling Defective CFTR causes cystic fibrosis MAPK6/MAPK4 signaling UCH proteinases Ub-specific processing proteases CDT1 association with the CDC6:ORC:origin complex Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G2/M Checkpoints Ubiquitin Mediated Degradation of Phosphorylated Cdc25A Ubiquitin-dependent degradation of Cyclin D The role of GTSE1 in G2/M progression after G2 checkpoint FBXL7 down-regulates AURKA during mitotic entry and in early mitosis RUNX1 regulates transcription of genes involved in differentiation of HSCs Regulation of RUNX2 expression and activity Regulation of RUNX2 expression and activity Regulation of RUNX3 expression and activity Regulation of PTEN stability and activity Neddylation Regulation of expression of SLITs and ROBOs Interleukin-1 signaling Negative regulation of NOTCH4 signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Blood urea nitrogen levels ( 31152163) Breast size ( 27182965) Eosinophil counts ( 32888494) Granulocyte count ( 27863252) Heart rate variability traits ( 22174390) Lymphocyte percentage of white cells ( 32888494 27863252) Mean corpuscular hemoglobin ( 32888494 27863252 28017375) Mean corpuscular volume ( 29403010 32888494 27863252 28017375) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) PR interval ( 32439900) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Systolic blood pressure ( 30224653) Total grey matter volume ( 31530798) White blood cell count ( 32888494)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Logical memory (immediate recall) in Alzheimer's disease dementia ( 29274321)
Interacting Genes		262 interacting genes: ABCF3 ADAM15 AMMECR1 ANAPC11 ANKMY1 APLN ARHGAP9 ARHGEF39 ARID5A ATN1 ATP6V0D1 ATP6V0E2 ATXN1 ATXN7L2 BANP BBS2 BCL6B BHLHE40 BOLL C10orf55 C11orf87 C19orf54 C1orf94 C20orf85 C22orf39 C9orf24 CAMK2A CAMK2B CCDC120 CCER1 CCNG1 CCNK CDC23 CDC42EP1 CDK6 CHCHD7 CLPP CNNM3 COL8A1 CRBN CREB5 CRX CRYBA1 CSN3 CSNK1G2-AS1 CYBA DAZAP2 DCAF8 DCDC2B DCTN5 DMRT3 DMRTB1 DOK3 DOK6 DPYSL4 DTX2 DVL2 EAF2 EFEMP2 ENKD1 EWSR1 EXOSC1 EYA2 FAM124B FAM166B FAM168A FASTK FBF1 FBXL18 FNDC11 FOXC2 FOXP3 FOXS1 FRG1 FXR2 GATA1 GATA2 GATAD2B GCM2 GLIS2 GLYCTK GPATCH2L GPS2 GRAP GRAP2 GSE1 HCK HEY2 HEYL HIVEP1 HNRNPLL HOXA1 HOXA9 HOXB9 HOXC8 HSFY1 IGF2 ILF3 INCA1 INIP IP6K2 KCTD9 KIF1A KIR2DL4 KLHDC7B KPNA2 KRAS KRTAP11-1 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP13-1 KRTAP13-3 KRTAP15-1 KRTAP19-1 KRTAP19-3 KRTAP19-5 KRTAP19-7 KRTAP23-1 KRTAP26-1 KRTAP3-1 KRTAP8-1 LASP1 LGALS9C LINC00482 LINC00588 LINC00908 LINC01547 LINC01588 LINC01869 LMO4 LONRF1 LRRC41 LZTS2 MAGED1 MCM5 MCM7 MEIS2 MGAT5B MKRN3 MLLT10 MORN3 MRPL20-AS1 MSX1 MVP MYH7B MYOZ2 NAB2 NANOG NAPRT NEDD9 NEU4 NKX2-5 NR1D2 NTAQ1 NYNRIN OTX1 PATZ1 PDLIM4 PER1 PGLS PHF1 PICALM PIH1D1 PIN1 PITX1 PITX2 PLAC8 PLSCR4 POGZ POLR3GL POM121 POU4F2 POU6F2 PPP1R16B PRKAA1 PRKAA2 PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR35 PSG11 PSMF1 QKI R3HDM2 RABL6 RAD54L2 RAMAC RBFOX1 RBFOX2 RBM24 RBM46 RBPMS2 RDH12 RHOBTB3 RHOXF2 RIPPLY1 ROR2 RPP25 RTP5 RUSC1 SBF2 SEMA4G SERF2 SF1 SFI1 SH3RF2 SIRPB1 SLC25A48 SMAD3 SMAP1 SMUG1 SNHG29 SNRPB SNRPC SPATA46 SPATA8 SPG7 STRBP TBX6 TCEA2 TCF7L2 TEKT5 TENT2 TEX37 TFG TIE1 TINAGL1 TLE5 TMEM42 TMSB4X TNS2 TOLLIP TOR1AIP2 TRAF4 TRIP13 TSC1 TSG101 TSGA10IP TSPYL6 TTLL10 TUSC2 UBAP2 VENTX VEZF1 VGLL3 VHL VHLL VPS37C WDR54 WDR90 YPEL3 ZBTB32 ZC3H10 ZIC1 ZNF34 ZNF385C ZNF488 ZNF581	36 interacting genes: BEND7 CCDC85B CD2BP2 CRX CTBP2 DVL2 DVL3 GATA1 HOOK2 IKZF3 KHDRBS2 KHDRBS3 LDOC1 LNX1 LNX2 MAGEA11 MAGED1 MIEF2 NUDT21 PAK5 PDLIM7 PSMA7 QKI RAB33A RALYL RBFOX1 RBFOX2 RBMX RBPMS RHOXF2 RNF126 TENT5B TLE5 TRAF2 TRIM73 WWP2
Entrez ID		11030	9491
HPRD ID		11870	17919
Ensembl ID		ENSG00000157110	ENSG00000125818
Uniprot IDs		B4E3T4 D3DSV0 Q93062	A0A140VJT2 B4DXW9 Q5QPM7 Q92530
PDB IDs		1BNY 5CYJ 5DET	2VT8 4OUH
Enriched GO Terms of Interacting Partners?
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