SPIN1 and GABBR2

Data Source:
BioGRID (proximity labelling technology)

		SPIN1	GABBR2
Description		spindlin 1	gamma-aminobutyric acid type B receptor subunit 2
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Nuclear Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane GABA Receptor Complex
	Molecular Function	Protein Binding Methylated Histone Binding	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Chromatin Organization Regulation Of Transcription, DNA-templated Multicellular Organism Development Gamete Generation RRNA Transcription Wnt Signaling Pathway Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transcription, DNA-templated Meiotic Cell Cycle	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuron-glial Cell Signaling
Pathways			Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil
Diseases
GWAS		Height ( 20881960 31562340 18391951) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectories ( 27980656)
Interacting Genes		4 interacting genes: HSPB1 PRMT6 PTN RPL5	11 interacting genes: ATF4 ATF5 DRD2 GABBR1 GLP1R HTR1A KCTD12 KCTD16 NSF SH3GL3 TAMALIN
Entrez ID		10927	9568
HPRD ID		18096	09552
Ensembl ID		ENSG00000106723	ENSG00000136928
Uniprot IDs		A0A024R297 Q9Y657	H9NIL8 O75899
PDB IDs		2NS2 4H75 4MZF 4MZG 4MZH 5JSG 5JSJ 5Y5W 6I8B 6I8L 6I8Y 6QPL 7BQZ 7BU9	4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S
Enriched GO Terms of Interacting Partners?
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