COPS8 and ITPK1

Data Source:
HPRD (in vitro)

		COPS8	ITPK1
Description		COP9 signalosome subunit 8	inositol-tetrakisphosphate 1-kinase
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol COP9 Signalosome Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Apical Plasma Membrane
	Molecular Function	Protein Binding	Magnesium Ion Binding Inositol Tetrakisphosphate 6-kinase Activity Catalytic Activity ATP Binding Hydrolase Activity Isomerase Activity Inositol Tetrakisphosphate 1-kinase Activity Inositol-1,3,4-trisphosphate 6-kinase Activity Inositol-1,3,4-trisphosphate 5-kinase Activity
	Biological Process	Protein Deneddylation Nucleotide-excision Repair, DNA Damage Recognition Transcription-coupled Nucleotide-excision Repair Protein Phosphorylation Activation Of NF-kappaB-inducing Kinase Activity Negative Regulation Of Cell Population Proliferation COP9 Signalosome Assembly Post-translational Protein Modification	Signal Transduction Blood Coagulation Neural Tube Development Inositol Trisphosphate Metabolic Process Inositol Phosphate Metabolic Process Inositol Phosphorylation Necroptotic Process
Pathways		DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation	Synthesis of pyrophosphates in the cytosol Synthesis of IP3 and IP4 in the cytosol Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Asthma ( 27611488) Body mass index ( 25673413) Coronary artery disease ( 33020668) Lung cancer ( 28604730) Motion sickness ( 25628336) Pulse pressure ( 27841878) Systemic lupus erythematosus ( 19838195)	Body mass index ( 26426971) Chronic obstructive pulmonary disease ( 30804561) Endometriosis ( 23472165) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Height ( 31562340) Migraine ( 27182965 27322543) Platelet count ( 22139419 32888494) Plateletcrit ( 32888494 27863252) Thyroid hormone levels ( 23408906) Thyroid stimulating hormone levels ( 32769997) White blood cell count ( 32888494)
Interacting Genes		17 interacting genes: COPS2 COPS3 COPS4 COPS5 COPS6 COPS7A CUL1 CUL5 DDB1 EIF3E GPS1 ITPK1 MAPRE1 NFKBIA SUOX TP53 USHBP1	6 interacting genes: COPS8 GPS1 JUN NFKBIA TP53 TRAF2
Entrez ID		10920	3705
HPRD ID		16737	03501
Ensembl ID		ENSG00000198612	ENSG00000100605
Uniprot IDs		A0A024R4D1 Q99627	A0A024R6H3 Q13572
PDB IDs		4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N	2ODT 2Q7D 2QB5
Enriched GO Terms of Interacting Partners?
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