FRS3 and MATK

Data Source:
BioGRID (two hybrid)

		FRS3	MATK
Description		fibroblast growth factor receptor substrate 3	megakaryocyte-associated tyrosine kinase
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GO Annotations	Cellular Component	Plasma Membrane	Cytosol Membrane
	Molecular Function	Fibroblast Growth Factor Receptor Binding Protein Binding Identical Protein Binding	Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding
	Biological Process	MAPK Cascade Signal Transduction Fibroblast Growth Factor Receptor Signaling Pathway	Protein Phosphorylation Positive Regulation Of Cell Population Proliferation Peptidyl-tyrosine Phosphorylation ERBB2 Signaling Pathway
Pathways		FRS-mediated FGFR1 signaling FRS-mediated FGFR2 signaling FRS-mediated FGFR3 signaling FRS-mediated FGFR4 signaling RAF/MAP kinase cascade Activated NTRK2 signals through FRS2 and FRS3	Downregulation of ERBB2 signaling
Drugs			Fostamatinib
Diseases
GWAS		Menarche (age at onset) ( 25231870)	Obesity-related traits ( 23251661)
Interacting Genes		111 interacting genes: ADAMTSL4 ANAPC11 ANKRD55 ATP23 BLZF1 BMPR2 C11orf1 C11orf45 C19orf54 C22orf39 CATSPER1 CBY2 CCDC33 CCN3 CDPF1 COL8A1 COPS3 CREB5 CYSRT1 DCDC2B DDX5 DMRT3 DPEP2NB ECM1 ESM1 FGFR1 GATA1 GPRIN2 GRB14 GRB2 HOXA1 HOXD12 ID2 ID3 IKZF3 INCA1 ISY1-RAB43 KARS1 KATNBL1 KIAA0408 KPRP KRT31 KRT33B KRT34 KRT35 KRT76 KRTAP1-1 KRTAP10-8 KRTAP11-1 KRTAP3-1 KRTAP3-2 KRTAP6-2 LINGO1 LRRC18 MAPK1 MATK MBD3L1 MIIP NADSYN1 NBPF19 NOTCH2NLA NTRK1 NTRK2 NUMB PCSK5 PDLIM7 PIH1D2 PLB1 PLLP PLSCR1 POF1B PPP1R32 PRDM6 PRKCI PTPN11 RFX6 RIMBP3C RND1 SCNM1 SH2B1 SLAIN1 SLC22A18AS SOCS6 SPATA12 SPRY2 STH STK16 TCF4 TCP10L TGM7 TLE5 TNS1 TRAF4 TRIP6 TSC1 TSGA10IP TSPAN4 UNKL VASP VGLL3 WDR83 WWOX YPEL3 ZMIZ2 ZNF124 ZNF417 ZNF438 ZNF446 ZNF552 ZNF69 ZSCAN30	24 interacting genes: AKT1 AR CACNA1A CD36 ERBB2 ERBB3 ERBB4 EWSR1 FRS3 HSPA5 HSPA9 ILK KIT LRRK1 LRRK2 LYN MET NTRK1 PTK2B PTPRD PXN SIRPA SMURF1 SRC
Entrez ID		10817	4145
HPRD ID		06373	02496
Ensembl ID		ENSG00000137218	ENSG00000007264
Uniprot IDs		A0A140VJJ7 O43559	F1T0G6 P42679
PDB IDs		2KUP 2KUQ 2YS5 2YT2	1JWO 1X6G 3US4
Enriched GO Terms of Interacting Partners?
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