SEPTIN9 and RAB10

Data Source:
HPRD (two hybrid)

		SEPTIN9	RAB10
Description		septin 9	RAB10, member RAS oncogene family
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GO Annotations	Cellular Component	Stress Fiber Cytoplasm Microtubule Axoneme Septin Ring Actin Cytoskeleton Microtubule Cytoskeleton Septin Complex Cell Division Site Perinuclear Region Of Cytoplasm Non-motile Cilium	Golgi Membrane Exocyst Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Adherens Junction Focal Adhesion Cilium Synaptic Vesicle Cytoplasmic Vesicle Membrane Secretory Granule Membrane Phagocytic Vesicle Membrane Insulin-responsive Compartment Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Exocytic Vesicle Endoplasmic Reticulum Tubular Network
	Molecular Function	GTPase Activity Protein Binding GTP Binding Cadherin Binding Molecular Adaptor Activity	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding Cadherin Binding Involved In Cell-cell Adhesion
	Biological Process	Cellular Protein Localization Cytoskeleton-dependent Cytokinesis Positive Regulation Of Non-motile Cilium Assembly	Golgi To Plasma Membrane Transport Vesicle Docking Involved In Exocytosis Axonogenesis Protein Secretion Vesicle-mediated Transport Endosomal Transport Regulation Of Exocytosis Antigen Processing And Presentation Polarized Epithelial Cell Differentiation Cellular Response To Insulin Stimulus Golgi To Plasma Membrane Protein Transport Neutrophil Degranulation Regulated Exocytosis Establishment Of Neuroblast Polarity Endoplasmic Reticulum Tubular Network Organization Protein Localization To Plasma Membrane Establishment Of Protein Localization To Membrane Establishment Of Protein Localization To Endoplasmic Reticulum Membrane Cell-cell Adhesion Protein Localization To Basolateral Plasma Membrane
Pathways			Translocation of SLC2A4 (GLUT4) to the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases		Hereditary neuralgic amyotrophy (HNA); Hereditary brachial plexus neuropathy
GWAS			Apolipoprotein B levels ( 32203549) Immune response to smallpox vaccine (IL-6) ( 22542470) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494 27863252) Metabolite levels (HVA) ( 23319000) Metabolite levels (HVA-5-HIAA Factor score) ( 23319000) Metabolite levels (HVA/MHPG ratio) ( 23319000) Platelet distribution width ( 32888494)
Interacting Genes		16 interacting genes: APP HIF1A HNRNPD HSF2BP IKBKG LINC00839 LINC01554 NEDD4 PTPRF RAB10 SEPTIN1 SEPTIN11 SEPTIN2 SEPTIN6 SEPTIN7 STK11	9 interacting genes: APP ENOPH1 EVI5L MICAL1 MTNR1A PPBP RABIF RIMS1 SEPTIN9
Entrez ID		10801	10890
HPRD ID		10360	06692
Ensembl ID		ENSG00000184640	ENSG00000084733
Uniprot IDs		A0A0S2Z5A5 Q9UHD8	P61026
PDB IDs		4YQF 5CYO 5CYP	5LPN 5SZJ
Enriched GO Terms of Interacting Partners?
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