AHCYL1 and PLEKHG5

Data Source:
BioGRID (two hybrid)

		AHCYL1	PLEKHG5
Description		adenosylhomocysteinase like 1	pleckstrin homology and RhoGEF domain containing G5
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Apical Plasma Membrane Mitochondria-associated Endoplasmic Reticulum Membrane Extracellular Exosome	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Lamellipodium Endocytic Vesicle Axon Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Adenosylhomocysteinase Activity Protein Binding Identical Protein Binding
	Biological Process	MRNA Polyadenylation Protein Export From Nucleus One-carbon Metabolic Process Apoptotic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Anion Transport Response To Calcium Ion Regulation Of Cardiac Conduction Mitochondrion-endoplasmic Reticulum Membrane Tethering	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Endothelial Cell Chemotaxis Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Endothelial Cell Migration Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases			Spinal muscular atrophy (SMA), including: SMA type I (SMA1) / Werdning-Hoffman disease; SMA type II (SMA2); SMA type III (SMA3) / Kugeleberg-Welander disease; SMA type IV (SMA4); X-linked SMA 2 (SMAX2); X-linked distal SMA 3 (DSMAX); Distal SMA autosomal recessive type 4 (DSMA4); Congenital distal spinal muscular atrophy (SMAL); SMA proximal adult autosomal dominant (SMAPAD)
GWAS		Height ( 31562340)	Multiple sclerosis ( 24076602) QT interval ( 19305408)
Interacting Genes		25 interacting genes: BID CDKN2C DACH1 GEM HBQ1 HEXIM2 HGS HSPA6 ITPR1 JOSD2 LRRK2 MEOX2 MFHAS1 PLEKHG5 PPL PRDM6 PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 SUMO2 UACA ZNF165	1 interacting genes: AHCYL1
Entrez ID		10768	57449
HPRD ID		07613	11104
Ensembl ID		ENSG00000168710	ENSG00000171680
Uniprot IDs		A0A024R0A8 O43865	O94827
PDB IDs		3MTG
Enriched GO Terms of Interacting Partners?
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