PTGES3 and STIP1

Data Source:
BioGRID (biochemical)
HPRD (in vitro)

		PTGES3	STIP1
Description		prostaglandin E synthase 3	stress induced phosphoprotein 1
Image
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nucleus Nucleoplasm Telomerase Holoenzyme Complex Cytosol Protein-containing Complex Chaperone Complex	Nucleus Golgi Apparatus Cytosol Protein-containing Complex Chaperone Complex
	Molecular Function	Telomerase Activity Protein Binding Prostaglandin-E Synthase Activity Unfolded Protein Binding Chaperone Binding Hsp90 Protein Binding DNA Polymerase Binding	RNA Binding Protein Binding Protein C-terminus Binding Hsp70 Protein Binding Chaperone Binding Hsp90 Protein Binding
	Biological Process	Telomere Maintenance Prostaglandin Biosynthetic Process Protein Folding Xenobiotic Metabolic Process Telomere Maintenance Via Telomerase Signal Transduction Cyclooxygenase Pathway Positive Regulation Of Phosphorylation Protein Stabilization Chaperone Cofactor-dependent Protein Refolding Chaperone-mediated Protein Complex Assembly Positive Regulation Of Telomerase Activity Regulation Of Cellular Response To Heat Telomerase Holoenzyme Complex Assembly	Cellular Response To Interleukin-7
Pathways		Synthesis of Prostaglandins (PG) and Thromboxanes (TX) HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase Aryl hydrocarbon receptor signalling ESR-mediated signaling Estrogen-dependent gene expression Potential therapeutics for SARS	HSP90 chaperone cycle for steroid hormone receptors (SHR)
Drugs		Acetaminophen Grn163l Copper	Copper
Diseases
GWAS		Asthma ( 31619474) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 27863252) Mean platelet volume ( 22139419) Platelet count ( 22139419) Reticulocyte count ( 32888494)	Attention deficit hyperactivity disorder ( 21784300) Crohn's disease ( 28067908) Fruit consumption ( 32066663)
Interacting Genes		29 interacting genes: AHR AHSA1 AIP ARNT CASP3 CASP7 CAV3 CD2AP CDC37 COPG1 COPG2 DNAJB1 DNMT3A EIF2AK2 ERBB3 ESR1 FES GZMB HSF1 HSP90AA1 HSP90AB1 HSPA1A HSPB1 NR3C1 NR3C2 STIP1 SURF1 TERT THRA	23 interacting genes: ACD ACVR1 AIP APP CDC37 CLCN1 CLK1 EGFR ERBB2 FKBP4 FKBP5 HSP90AA1 HSPA14 HSPA1A HSPA1B HSPA8 LMO2 MAP3K8 POT1 PRNP PTGES3 SUMO2 SUMO4
Entrez ID		10728	10963
HPRD ID		06138	05454
Ensembl ID		ENSG00000110958	ENSG00000168439
Uniprot IDs		A0A024RB32 A0A087WYT3 B3KUY2 Q15185	P31948 V9HW72
PDB IDs		1EJF 1LG0	1ELR 1ELW 2LNI 2NC9 3ESK 3FWV
Enriched GO Terms of Interacting Partners?
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