CFL1 and TAB1

Data Source:
BioGRID (two hybrid)

		CFL1	TAB1
Description		cofilin 1	TGF-beta activated kinase 1 (MAP3K7) binding protein 1
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Cytosol Focal Adhesion Actin Cytoskeleton Membrane Nuclear Matrix Lamellipodium Lamellipodium Membrane Vesicle Ruffle Membrane Extracellular Exosome	Nucleus Cytosol Endosome Membrane Nuclear Speck Protein-containing Complex
	Molecular Function	Protein Binding Actin Filament Binding	Magnesium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Enzyme Activator Activity Kinase Activator Activity Protein-containing Complex Binding Mitogen-activated Protein Kinase P38 Binding
	Biological Process	Cytoskeleton Organization Rho Protein Signal Transduction Response To Virus Viral Process Regulation Of Cell Morphogenesis Actin Cytoskeleton Organization Actin Filament Depolymerization Actin Filament Fragmentation Interleukin-12-mediated Signaling Pathway Positive Regulation Of Embryonic Development Negative Regulation Of Apoptotic Process Positive Regulation By Host Of Viral Process Cell Motility Actin Filament Severing Establishment Of Spindle Localization Regulation Of Dendritic Spine Morphogenesis	Activation Of MAPKKK Activity Activation Of MAPK Activity In Utero Embryonic Development Stimulatory C-type Lectin Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Heart Morphogenesis Cardiac Septum Development Negative Regulation Of Protein Kinase Activity Protein Dephosphorylation Transforming Growth Factor Beta Receptor Signaling Pathway I-kappaB Kinase/NF-kappaB Signaling JNK Cascade Protein Deubiquitination Lung Development Aorta Development Fc-epsilon Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Coronary Vasculature Development Nucleotide-binding Oligomerization Domain Containing Signaling Pathway Interleukin-1-mediated Signaling Pathway
Pathways		Platelet degranulation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling Sema3A PAK dependent Axon repulsion RHO GTPases Activate ROCKs Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	NOD1/2 Signaling Pathway FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 TNFR1-induced NFkappaB signaling pathway CLEC7A (Dectin-1) signaling Ub-specific processing proteases TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
Drugs		Dodecyldimethylamine N-oxide Copper Artenimol	Manganese
Diseases
GWAS		Acne (severe) ( 24927181) Basal cell carcinoma ( 31174203) Breast cancer ( 23535729) DNA methylation (variation) ( 23725790) Keratinocyte cancer (MTAG) ( 31174203) Neutrophil count ( 32888494) Platelet count ( 32888494) Psoriasis ( 28537254) White blood cell count ( 32888494)	Factor VIII levels ( 30586737) IgG bisecting N-acetyl glucosamine phenotypes (multivariate analysis) ( 28878392) IgG digalactosylation phenotypes (multivariate analysis) ( 28878392) IgG disialylation phenotypes (multivariate analysis) ( 28878392) IgG fucosylation phenotypes (multivariate analysis) ( 28878392) IgG galactosylation phenotypes (multivariate analysis) ( 28878392) IgG glycosylation ( 23382691) IgG monogalactosylation phenotypes (multivariate analysis) ( 28878392) IgG N-glycosylation phenotypes (multivariate analysis) ( 28878392) IgG sialylation phenotypes (multivariate analysis) ( 28878392) Inflammatory bowel disease ( 23128233) Intelligence (MTAG) ( 29326435) Schizophrenia ( 29483656) Sleep duration (short sleep) ( 30846698) vWF levels ( 30586737) Waist circumference ( 28552196)
Interacting Genes		43 interacting genes: ACTA1 ACTA2 ACTB ACTC1 ACTG1 APP ATP1A1 ATXN1 CFL2 CLCN5 EGFR ERBB2 ERBB3 ERBB4 ESR1 HSPH1 LIMK1 LIMK2 MAPK6 MAPK8IP2 MYCBP NRK POT1 PSEN1 PTEN RAD21 RPS6KA1 SLC2A4 SRC SSH1 SSH2 SSH3 TAB1 TERF1 TESK1 TESK2 TPI1 TRIM15 UCHL5 WDR1 YWHAG YWHAQ YWHAZ	74 interacting genes: AATK ACAP3 ARAP1 ASRGL1 BMPR1A C9orf78 CARD11 CASP6 CDK5RAP3 CFL1 CKB CORO1A DBN1 DVL2 EGFR EPRS1 ERBB4 FADD FN1 GIT1 HNRNPR IKBKG ITCH KIFC2 LAP3 LCMT1 LGALS7 LGALS7B LNX2 MAP3K1 MAP3K7 MAPK11 MAPK14 MAPKAPK5 MICAL1 MON1A MTG2 NR2C2 NXPH3 OGT PDCD6IP PHACTR3 PHC2 POLDIP2 POLR3D PPP1R7 PPP2CB PPP2R1A PRKAR1A PTPMT1 RBX1 ROR2 RPL10 RPLP1 SERPINA4 SMAD6 SMAD7 SMURF1 SNRNP35 TAB2 TAB3 TRAF2 TRAF6 TRIP6 TRPC4AP TSSC4 UBC URB1 WDCP WTAP XIAP XPO7 YWHAG ZMYND11
Entrez ID		1072	10454
HPRD ID		03261	04012
Ensembl ID		ENSG00000172757	ENSG00000100324
Uniprot IDs		P23528 V9HWI5	A8K6K3 Q15750
PDB IDs		1Q8G 1Q8X 3J0S 4BEX 5HVK 5L6W 6UBY 6UC0 6UC4 6VAO	2J4O 2POM 2POP 2YDS 2YIY 4AY5 4AY6 4GS6 4KA3 4L3P 4L52 4L53 4O91 5DIY 5E7R 5GJD 5GJF 5GJG 5J7S 5J8I 5J9L 5JGA 5JGB 5JGD 5JH6 5JK3 5NZZ 5O90 5V5N 5VVU
Enriched GO Terms of Interacting Partners?
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