CES1 and GUSB

Data Source:
HPRD (in vivo, in vitro)

		CES1	GUSB
Description		carboxylesterase 1	glucuronidase beta
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GO Annotations	Cellular Component	Extracellular Space Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Lumen Lipid Droplet Cytosol	Extracellular Region Extracellular Space Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Sterol Esterase Activity Triglyceride Lipase Activity Methylumbelliferyl-acetate Deacetylase Activity Carboxylic Ester Hydrolase Activity Methyl Indole-3-acetate Esterase Activity	Beta-glucuronidase Activity Signaling Receptor Binding Protein Domain Specific Binding Carbohydrate Binding
	Biological Process	Angiotensin Maturation Cholesterol Biosynthetic Process Xenobiotic Metabolic Process Cholesterol Metabolic Process Response To Toxic Substance Positive Regulation Of Cholesterol Efflux Negative Regulation Of Cholesterol Storage Lipid Catabolic Process Epithelial Cell Differentiation Cholesterol Homeostasis Reverse Cholesterol Transport Medium-chain Fatty Acid Metabolic Process Regulation Of Bile Acid Biosynthetic Process Cellular Response To Cholesterol Cellular Response To Low-density Lipoprotein Particle Stimulus Cholesterol Ester Hydrolysis Involved In Cholesterol Transport Positive Regulation Of Cholesterol Metabolic Process Regulation Of Bile Acid Secretion	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Glucuronoside Catabolic Process Hyaluronan Catabolic Process Neutrophil Degranulation
Pathways		Metabolism of Angiotensinogen to Angiotensins Phase I - Functionalization of compounds	HS-GAG degradation Hyaluronan uptake and degradation MPS VII - Sly syndrome Neutrophil degranulation
Drugs		Tacrine Meperidine Levocarnitine Dextropropoxyphene Cocaine Naloxone Diamorphine Probucol Hydroxy-Phenyl-Acetic Acid 8-Methyl-8-Aza-Bicyclo[3.2.1]Oct-3-Yl Ester Cholic Acid 4-Piperidino-Piperidine N-acetyl-alpha-neuraminic acid Thenoyltrifluoroacetone Cyclandelate Avasimibe (1R)-1,2,2-trimethylpropyl (R)-methylphosphinate (1S,7S,8S,8AR)-1,2,3,7,8,8A-HEXAHYDRO-7-METHYL-8-[2-[(2R,4R)-TETRAHYDRO-4-HY DROXY-6-OXO-2H-PYRAN-2-YL]ETHYL]-1-NAPHTHALENOL
Diseases			Mucopolysaccharidosis type VII (MPS7); Sly syndrome
GWAS		Response to dabigatran etexilate treatment ( 23467860)
Interacting Genes		10 interacting genes: BMPR2 CREB3 CYSRT1 GORAB GUSB KPRP PDZK1IP1 PLSCR4 SAR1A VENTX	3 interacting genes: CES1 GIT2 PRKACA
Entrez ID		1066	2990
HPRD ID		00268	02018
Ensembl ID		ENSG00000198848	ENSG00000169919
Uniprot IDs		P23141	P08236
PDB IDs		1MX1 1MX5 1MX9 1YA4 1YA8 1YAH 1YAJ 2DQY 2DQZ 2DR0 2H7C 2HRQ 2HRR 3K9B 4AB1 5A7F 5A7G 5A7H	1BHG 3HN3
Enriched GO Terms of Interacting Partners?
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