KHDRBS1 and UBASH3B

Data Source:
BioGRID (unspecified method)

		KHDRBS1	UBASH3B
Description		KH RNA binding domain containing, signal transduction associated 1	ubiquitin associated and SH3 domain containing B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Membrane Protein-containing Complex Grb2-Sos Complex	Nucleus Cytoplasm
	Molecular Function	DNA Binding RNA Binding MRNA Binding Protein Binding Poly(A) Binding Poly(U) RNA Binding SH3 Domain Binding Protein Domain Specific Binding Signaling Adaptor Activity SH2 Domain Binding Identical Protein Binding Protein-containing Complex Binding Protein Tyrosine Kinase Binding	Protein Tyrosine Phosphatase Activity Protein Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Phosphoprotein Binding
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA Processing Spermatogenesis Regulation Of Protein Stability Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Translational Initiation Regulation Of RNA Export From Nucleus Positive Regulation Of RNA Export From Nucleus Regulation Of MRNA Splicing, Via Spliceosome T Cell Receptor Signaling Pathway	Negative Regulation Of Protein Kinase Activity Negative Regulation Of Signal Transduction Peptidyl-tyrosine Dephosphorylation Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Regulation Of Protein Binding Regulation Of Osteoclast Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Platelet Aggregation Negative Regulation Of Platelet Aggregation
Pathways		PTK6 Regulates Proteins Involved in RNA Processing
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Blood urea nitrogen levels ( 31152163) Cholesterol, total ( 24097068 25961943 20686565) Chronotype ( 30696823) Diastolic blood pressure ( 30224653) Eye length ( 30174134) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 32203549) High light scatter reticulocyte percentage of red cells ( 32888494) LDL cholesterol levels ( 32203549) Low density lipoprotein cholesterol levels ( 32154731) Multiple sclerosis and HDL levels (pleiotropy) ( 26920376) Pemphigus vulgaris ( 29857070) Serum immune biomarker levels ( 32066700) Stroke ( 26089329) Systolic blood pressure ( 30578418) Total cholesterol levels ( 28334899)
Interacting Genes		110 interacting genes: ABI2 ACTB AGO1 AHI1 AMPH APBB1 ARHGEF4 ARHGEF9 AZIN1 BAIAP2L1 BTK CBL CD2AP CDC42 CDK1 CIRBP CLK1 CREB3L3 CREBBP CRK CRKL CSK DDX5 DHX9 DLG1 DLG2 DLG3 DLG4 DNMBP DOCK2 DOCK3 EFEMP1 EMG1 FGR FNBP4 FRK FYN GAS7 GPHN GRAP GRAP2 GRB2 HCK HNRNPK INSR ITK ITPRID2 ITSN1 ITSN2 JAK3 KHDRBS3 LCK LYN MAPK1 MYO1C MYO7A NCF1 NCK1 NCK2 NCKIPSD NPHP1 OSTF1 PACSIN1 PALS2 PIK3R1 PIK3R3 PLCG1 PLCG2 POT1 PPP1R13B PRMT1 PSTPIP1 PTBP2 PTK6 PTPN6 RALY RAPSN RASA1 RBFOX2 RBM7 RBMX RUSC2 SASH1 SCG5 SH3PXD2A SH3YL1 SKAP2 SMAD2 SMARCA2 SNX30 SNX9 SORBS1 SPATA13 SRC SRPK2 STAT3 STUB1 TBL1X TJP1 TSPOAP1 TUBB3 UBA52 UBASH3B UBC VAV1 WBP4 YES1 YTHDC1 ZBTB7A ZDHHC6	51 interacting genes: BBC3 CBL CBLB CCDC74B CUL3 DAZAP2 DISC1 DLGAP2 DMRT3 DOC2A DTX3 EFS FAM168A HOXB2 INCA1 JAK2 KAT5 KDM1A KHDRBS1 KPRP LMO2 LZTS2 MAP3K1 PIAS2 PKP4 PRKN PRR35 PSMB1 PTPN21 RCHY1 REL RNF216 RNF41 SHC1 SLC25A48 SPRY2 SYK TCF4 TEPSIN TNKS TP53BP2 UBB UBC UBE2C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H VPS37B WASL
Entrez ID		10657	84959
HPRD ID		03926	16463
Ensembl ID		ENSG00000121774	ENSG00000154127
Uniprot IDs		Q07666	Q8TF42
PDB IDs		2XA6 3QHE	2CPW 2E5K 5VR6 5W5G
Enriched GO Terms of Interacting Partners?
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