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KHDRBS3 and PSMF1
Data Source:
HPRD
(two hybrid)
KHDRBS3
PSMF1
Description
KH RNA binding domain containing, signal transduction associated 3
proteasome inhibitor subunit 1
Image
GO Annotations
Cellular Component
Nucleus
Nucleoplasm
Protein-containing Complex
Nucleoplasm
Endoplasmic Reticulum
Cytosol
Proteasome Core Complex
Membrane
Perinuclear Region Of Cytoplasm
Molecular Function
RNA Binding
MRNA Binding
Protein Binding
SH3 Domain Binding
Protein Domain Specific Binding
Identical Protein Binding
Endopeptidase Inhibitor Activity
Protein Binding
Protein Homodimerization Activity
Protein Heterodimerization Activity
Proteasome Binding
Biological Process
Regulation Of Alternative MRNA Splicing, Via Spliceosome
MRNA Processing
Viral Process
Regulation Of MRNA Splicing, Via Spliceosome
MAPK Cascade
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Ubiquitin-dependent Protein Catabolic Process
Regulation Of Cellular Amino Acid Metabolic Process
Negative Regulation Of Endopeptidase Activity
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Protein Deubiquitination
Anaphase-promoting Complex-dependent Catabolic Process
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Tumor Necrosis Factor-mediated Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Regulation Of MRNA Stability
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Transmembrane Transport
Wnt Signaling Pathway, Planar Cell Polarity Pathway
Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia
Interleukin-1-mediated Signaling Pathway
Negative Regulation Of Canonical Wnt Signaling Pathway
Positive Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Proteasomal Protein Catabolic Process
Regulation Of Mitotic Cell Cycle Phase Transition
Regulation Of Hematopoietic Stem Cell Differentiation
Pathways
PTK6 Regulates Proteins Involved in RNA Processing
Activation of NF-kappaB in B cells
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
ER-Phagosome pathway
Cross-presentation of soluble exogenous antigens (endosomes)
Autodegradation of Cdh1 by Cdh1:APC/C
SCF-beta-TrCP mediated degradation of Emi1
APC/C:Cdc20 mediated degradation of Securin
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
Cdc20:Phospho-APC/C mediated degradation of Cyclin A
Vpu mediated degradation of CD4
Vif-mediated degradation of APOBEC3G
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
Regulation of activated PAK-2p34 by proteasome mediated degradation
Separation of Sister Chromatids
FCERI mediated NF-kB activation
Autodegradation of the E3 ubiquitin ligase COP1
Regulation of ornithine decarboxylase (ODC)
ABC-family proteins mediated transport
AUF1 (hnRNP D0) binds and destabilizes mRNA
Asymmetric localization of PCP proteins
Degradation of AXIN
Degradation of DVL
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
Hedgehog 'on' state
Regulation of RAS by GAPs
TNFR2 non-canonical NF-kB pathway
NIK-->noncanonical NF-kB signaling
Defective CFTR causes cystic fibrosis
MAPK6/MAPK4 signaling
UCH proteinases
Ub-specific processing proteases
CDT1 association with the CDC6:ORC:origin complex
Orc1 removal from chromatin
CDK-mediated phosphorylation and removal of Cdc6
G2/M Checkpoints
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
Ubiquitin-dependent degradation of Cyclin D
The role of GTSE1 in G2/M progression after G2 checkpoint
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
RUNX1 regulates transcription of genes involved in differentiation of HSCs
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Regulation of RUNX3 expression and activity
Regulation of PTEN stability and activity
Neddylation
Regulation of expression of SLITs and ROBOs
Interleukin-1 signaling
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
Chronotype (
30696823
)
Disease progression in age-related macular degeneration (
29346644
)
Polycystic ovary syndrome (
25574032
)
Squamous cell lung carcinoma (
28604730
)
Venous thromboembolism adjusted for sickle cell variant rs77121243-T (
28203683
)
Angiotensin-converting enzyme inhibitor intolerance (
28030426
)
Logical memory (immediate recall) in Alzheimer's disease dementia (
29274321
)
Interacting Genes
54 interacting genes:
AQP1
BAHD1
CACNA1A
CCDC187
CCDC33
CNNM3
DMRT3
DOCK2
FBXO7
FUS
HBZ
HNRNPC
HNRNPK
INPP5D
KHDRBS1
KHDRBS2
LMNTD2
LNX1
MARK4
MYPOP
NCOA5
NELFB
NUDT18
PCDHB14
PPP1R13B
PRMT1
PRPF31
PRR3
PSMA1
PSMF1
PTBP2
RASAL3
RASD1
RBBP6
RBM3
RBM7
RBMX
RBMY1A1
RFC3
RPH3AL
SGSM2
SIAH1
SNRPC
SNX18
SRSF9
TSGA10IP
TYK2
U2AF2
YTHDC1
ZNF326
ZNF408
ZNF575
ZNF580
ZNF688
36 interacting genes:
BEND7
CCDC85B
CD2BP2
CRX
CTBP2
DVL2
DVL3
GATA1
HOOK2
IKZF3
KHDRBS2
KHDRBS3
LDOC1
LNX1
LNX2
MAGEA11
MAGED1
MIEF2
NUDT21
PAK5
PDLIM7
PSMA7
QKI
RAB33A
RALYL
RBFOX1
RBFOX2
RBMX
RBPMS
RHOXF2
RNF126
TENT5B
TLE5
TRAF2
TRIM73
WWP2
Entrez ID
10656
9491
HPRD ID
10007
17919
Ensembl ID
ENSG00000131773
ENSG00000125818
Uniprot IDs
O75525
A0A140VJT2
B4DXW9
Q5QPM7
Q92530
PDB IDs
5EL3
5ELR
5ELS
5ELT
5EMO
2VT8
4OUH
Enriched GO Terms of Interacting Partners
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