PRPF8 and GPKOW

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		PRPF8	GPKOW
Description		pre-mRNA processing factor 8	G-patch domain and KOW motifs
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U5 SnRNP Membrane Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome U2-type Catalytic Step 1 Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome	Nucleus Nucleoplasm Spliceosomal Complex
	Molecular Function	RNA Binding Protein Binding Metallopeptidase Activity U6 SnRNA Binding U1 SnRNA Binding U2 SnRNA Binding U5 SnRNA Binding Isopeptidase Activity K63-linked Polyubiquitin Modification-dependent Protein Binding Pre-mRNA Intronic Binding	RNA Binding Protein Binding
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing Proteolysis RNA Splicing Cellular Response To Lipopolysaccharide Cellular Response To Tumor Necrosis Factor	MRNA Splicing, Via Spliceosome
Pathways		mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway	mRNA Splicing - Major Pathway
Drugs
Diseases		Retinitis pigmentosa (RP)
GWAS		Blood protein levels ( 28240269) Calcium levels ( 20705733) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Ischemic stroke ( 29531354) Stroke ( 29531354)
Interacting Genes		21 interacting genes: ABCA1 DHX9 DUX4 ERG GPKOW H2BC5 HNRNPH2 NEDD4 PIN1 PRPF19 PTEN RNF20 SERPINB2 SLC22A2 SND1 SNRNP200 SUMO2 TP53 UBC UBE2I ZNF830	48 interacting genes: APP ARMCX1 BUD13 CCDC57 CNKSR3 DDIT4L EFHC2 FBXO7 GMPPA GOLGA2 GSTM5 HOOK2 HSF2BP IKBKG KANK2 LNX1 LRP2BP LZTS1 MAD1L1 MEOX2 MESD MID2 MTUS2 NINL PHF1 PIBF1 PICK1 POLR2G PPP1CA PRKAR1B PRPF4 PRPF8 REL ROPN1 SH3GL1 SORBS3 SPDYE4 TCEA1 TCEA2 TERF2IP TRAF2 TRIM23 TRIM27 VPS52 WDR77 WDR83 ZMYND12 ZRANB1
Entrez ID		10594	27238
HPRD ID		06295	06737
Ensembl ID		ENSG00000174231	ENSG00000068394
Uniprot IDs		Q6P2Q9	Q92917
PDB IDs		3E9L 3ENB 3JCR 3LRU 4JK7 4JK8 4JK9 4JKA 4JKB 4JKC 4JKD 4JKE 4JKF 4JKG 4JKH 4KIT 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF4 6FF7 6ICZ 6ID0 6ID1 6QDV 6QW6 6QX9 6S8Q 6S9I 6ZYM 7A5P
Enriched GO Terms of Interacting Partners?
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