CENPA and DIAPH2

Data Source:
HPRD (in vivo, two hybrid)

		CENPA	DIAPH2
Description		centromere protein A	diaphanous related formin 2
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Nuclear Chromosome Kinetochore Condensed Chromosome, Centromeric Region Nucleosome Condensed Chromosome Inner Kinetochore Nucleus Nucleoplasm Pericentric Heterochromatin Cytosol	Nucleolus Early Endosome Endoplasmic Reticulum Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Protein Heterodimerization Activity	Actin Binding Signaling Receptor Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Mitotic Cytokinesis Viral Process CENP-A Containing Nucleosome Assembly Kinetochore Assembly Protein Localization To Chromosome, Centromeric Region	Actin Filament Organization Multicellular Organism Development Female Gamete Generation Oogenesis
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Deposition of new CENPA-containing nucleosomes at the centromere Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		11 interacting genes: AURKB AURKC CDKN2A CUL4A DIAPH1 DIAPH2 H3C3 H4C6 HJURP PARP1 PARP2	6 interacting genes: APBB1 CDC42 CENPA NCKIPSD RHOD TCERG1
Entrez ID		1058	1730
HPRD ID		00313	02117
Ensembl ID		ENSG00000115163	ENSG00000147202
Uniprot IDs		P49450	O60879
PDB IDs		3AN2 3NQJ 3NQU 3R45 3WTP 5CVD 5Z23 6BUZ 6C0W 6E0C 6E0P 6KDQ 6KDS 6L49 6MUO 6MUP 6O1D 6SE0 6SE6 6SEE 6SEF 6SEG 6TEM
Enriched GO Terms of Interacting Partners?
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