DPYSL4 and PTPRO

Data Source:
BioGRID (two hybrid)

		DPYSL4	PTPRO
Description		dihydropyrimidinase like 4	protein tyrosine phosphatase receptor type O
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GO Annotations	Cellular Component	Cytosol	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Apical Plasma Membrane Lateral Plasma Membrane Lamellipodium Axon Growth Cone Neuron Projection Dendritic Spine Extracellular Exosome Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Dihydropyrimidinase Activity Protein Binding Filamin Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Phosphatase Activity Wnt-protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Pyrimidine Nucleobase Catabolic Process Nervous System Development Neuron Death Neuron Projection Guidance	Cell Morphogenesis Monocyte Chemotaxis Regulation Of Glomerular Filtration Negative Regulation Of Glomerular Filtration Protein Dephosphorylation Axon Guidance Negative Regulation Of Cell-substrate Adhesion Negative Regulation Of Neuron Projection Development Lamellipodium Assembly Glomerulus Development Peptidyl-tyrosine Dephosphorylation Slit Diaphragm Assembly Glomerular Visceral Epithelial Cell Differentiation Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Retinal Ganglion Cell Axon Guidance Peptidyl-tyrosine Dephosphorylation Involved In Inactivation Of Protein Kinase Activity
Pathways		CRMPs in Sema3A signaling	Signaling by NTRK3 (TRKC)
Drugs
Diseases
GWAS		Metabolite levels ( 23823483)	Cognitive function ( 22126837) General cognitive ability ( 29844566) Glomerular filtration rate (creatinine) ( 26831199) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Intelligence (MTAG) ( 29326435) Obstetric antiphospholipid syndrome ( 28424481) Temporal pole volume ( 31530798)
Interacting Genes		9 interacting genes: DPYSL2 DPYSL5 PTPRO RBPMS SH3GL1 SH3GL2 SH3GL3 TRIM54 TRIP13	9 interacting genes: ACTG1 APP DPPA4 DPYSL4 KIT PIM1 SH3GL1 SH3GL3 YWHAZ
Entrez ID		10570	5800
HPRD ID		07463	02784
Ensembl ID		ENSG00000151640	ENSG00000151490
Uniprot IDs		D3DRG7 O14531	A0A024RAS0 A0A024RAS9 Q16827
PDB IDs		5NKS	2G59 2GJT
Enriched GO Terms of Interacting Partners?
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