ARFGEF2 and PRKAR1A

Data Source:
HPRD (in vitro, in vivo, two hybrid)

		ARFGEF2	PRKAR1A
Description		ADP ribosylation factor guanine nucleotide exchange factor 2	protein kinase cAMP-dependent type I regulatory subunit alpha
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GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Trans-Golgi Network Microtubule Organizing Center Cytosol Axonemal Microtubule Membrane Cytoplasmic Vesicle Asymmetric Synapse Symmetric Synapse Dendritic Spine Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome	Immunological Synapse Cytoplasm Multivesicular Body Centrosome Cytosol Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Neuromuscular Junction Protein-containing Complex Plasma Membrane Raft Sperm Connecting Piece Ciliary Base Glutamatergic Synapse
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Myosin Binding Protein Kinase A Regulatory Subunit Binding GABA Receptor Binding	CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding
	Biological Process	Receptor Recycling Exocytosis Golgi To Plasma Membrane Transport Endosome Organization Endomembrane System Organization Protein Transport Regulation Of ARF Protein Signal Transduction Positive Regulation Of Tumor Necrosis Factor Production Intracellular Signal Transduction Regulation Of Catalytic Activity	Mesoderm Formation Renal Water Homeostasis Regulation Of Transcription By RNA Polymerase II Female Meiotic Nuclear Division Blood Coagulation Regulation Of Protein Kinase A Signaling Activation Of Protein Kinase A Activity Intracellular Signal Transduction Regulation Of CAMP-mediated Signaling Sarcomere Organization Negative Regulation Of Meiotic Nuclear Division Negative Regulation Of Activated T Cell Proliferation Cardiac Muscle Cell Proliferation Cellular Response To Glucagon Stimulus Negative Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Association of TriC/CCT with target proteins during biosynthesis	PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production
Drugs			(Rp)-cAMPS Cyclic GMP Cyclic adenosine monophosphate GEM-231
Diseases		Periventricular nodular heterotopia (PVNH)	Pigmented micronodular adrenocortical disease (PPNAD)
GWAS		Adult body size ( 32376654) Anger ( 24489884) Birth weight ( 31043758) Extremely high intelligence ( 29520040) General cognitive ability ( 29844566) Height ( 28552196) Intelligence (MTAG) ( 29326435) Loneliness ( 29970889) Loneliness (MTAG) ( 29970889) Offspring birth weight ( 31043758) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in non-smokers ( 28443625)	Body size at age 10 ( 32376654) Coronary artery disease ( 33020668) Estimated glomerular filtration rate ( 31152163) Intake of total sugars ( 31005972)
Interacting Genes		9 interacting genes: ARFGEF1 EXOC7 GABRB1 GABRB2 GABRB3 PNPLA2 PRKAR1A PRKAR2A PRPF40A	47 interacting genes: AKAP1 AKAP10 AKAP11 AKAP4 AKAP5 AKAP7 ARFGEF2 BAHD1 C11orf49 C2orf88 CAPN11 CBS CCNE1 CDK2 CDK4 DTX1 EGFR FAM153B GRB2 HIVEP1 HLA-A ITGA4 MAPK6 MYO7A NELL2 PATZ1 PJA2 PLEKHF2 PRKACA PRKAR1B PRKX PRPF40A PYCARD RAF1 RFC2 RSPH3 SET SETD7 SLC2A4 SMAD2 SPART TAB1 TULP3 WDCP WNK1 YWHAZ ZBED1
Entrez ID		10564	5573
HPRD ID		09250	01786
Ensembl ID		ENSG00000124198	ENSG00000108946
Uniprot IDs		Q59FR3 Q86TH5 Q9Y6D5	B2R5T5 P10644
PDB IDs		3L8N 3SWV	5KJX 5KJY 5KJZ
Enriched GO Terms of Interacting Partners?
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