IPO8 and RANGAP1

Data Source:
HPRD (in vitro)

		IPO8	RANGAP1
Description		importin 8	Ran GTPase activating protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Envelope Nucleoplasm Cytosol	Kinetochore Condensed Chromosome Kinetochore Nuclear Envelope Nuclear Pore Nucleoplasm Cytoplasm Cytosol Aggresome Dendrite Nuclear Membrane Intracellular Membrane-bounded Organelle Nuclear Pore Cytoplasmic Filaments Perinuclear Region Of Cytoplasm Mitotic Spindle Axon Cytoplasm Cytoplasmic Periphery Of The Nuclear Pore Complex
	Molecular Function	Protein Binding Small GTPase Binding	RNA Binding GTPase Activator Activity Protein Binding Small GTPase Binding Ubiquitin Protein Ligase Binding Cadherin Binding
	Biological Process	Protein Import Into Nucleus Signal Transduction Regulation Of Gene Silencing By MiRNA	Signal Transduction Protein Sumoylation Negative Regulation Of Protein Export From Nucleus Response To Axon Injury Activation Of GTPase Activity Cellular Response To Vasopressin
Pathways		Transcriptional regulation by small RNAs	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Rev-mediated nuclear export of HIV RNA Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion SUMO E3 ligases SUMOylate target proteins SUMOylation of DNA replication proteins RHO GTPases Activate Formins Mitotic Prometaphase Postmitotic nuclear pore complex (NPC) reformation EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Initial pursuit acceleration ( 29064472) Initial pursuit acceleration in psychotic disorders ( 29064472)	Adventurousness ( 30643258) Autism spectrum disorder or schizophrenia ( 28540026) Bitter beverage consumption ( 31046077) Heel bone mineral density ( 30598549) Lamb consumption ( 32066663) Medication use (adrenergics, inhalants) ( 31015401) Mood instability ( 31168069) Neuroticism ( 29255261) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		8 interacting genes: ATXN1 KPNB1 RANGAP1 SRP19 WT1 ZFP2 ZNF264 ZNF774	20 interacting genes: AXIN2 CCL5 CSNK2A1 DLC1 GNAI1 GNAI3 IPO8 MUL1 PDGFRL PTEN RAN RANBP2 SENP1 SENP2 SUMO1 SUMO2 SUMO3 UBE2E3 UBE2I USPL1
Entrez ID		10526	5905
HPRD ID		09282	03839
Ensembl ID		ENSG00000133704	ENSG00000100401
Uniprot IDs		O15397	A0A024R1U0 P46060 Q9BSK3
PDB IDs			1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2IO2 2IO3 2IY0 3UIN 3UIO 3UIP 5D2M
Enriched GO Terms of Interacting Partners?
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