HYOU1 and IL1R1

Data Source:
BioGRID (affinity chromatography technology)

		HYOU1	IL1R1
Description		hypoxia up-regulated 1	interleukin 1 receptor type 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Endoplasmic Reticulum Endoplasmic Reticulum Lumen Smooth Endoplasmic Reticulum Focal Adhesion Membrane Endoplasmic Reticulum Chaperone Complex Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane
	Molecular Function	Adenyl-nucleotide Exchange Factor Activity Protein Binding ATP Binding Unfolded Protein Binding Chaperone Binding	Protease Binding Transmembrane Signaling Receptor Activity Interleukin-1 Receptor Activity Interleukin-1, Type I, Activating Receptor Activity Platelet-derived Growth Factor Receptor Binding Protein Binding Interleukin-1 Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Response To Ischemia Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Receptor-mediated Endocytosis Response To Endoplasmic Reticulum Stress IRE1-mediated Unfolded Protein Response Regulation Of Catalytic Activity Cellular Response To Hypoxia Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway	Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Positive Regulation Of Interferon-gamma Production Regulation Of Inflammatory Response Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Positive Regulation Of Neutrophil Extravasation Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		Scavenging by Class F Receptors Scavenging by Class F Receptors XBP1(S) activates chaperone genes	Interleukin-10 signaling Interleukin-1 signaling Potential therapeutics for SARS
Drugs			Anakinra SD118 OMS-103HP Foreskin fibroblast (neonatal)
Diseases
GWAS		Post bronchodilator FEV1/FVC ratio ( 26634245)	Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29785011) Ankylosing spondylitis ( 23749187) Asthma ( 31959851 30929738 31619474 29785011 22561531) Asthma (childhood onset) ( 30929738) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Blood protein levels ( 30072576 28240269) C-reactive protein levels ( 30388399) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Inflammatory bowel disease ( 28067908 23128233) Primary biliary cholangitis ( 26394269) Serum protein levels (sST2) ( 23999434) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		3 interacting genes: CDC42 LINC01554 SEL1L	11 interacting genes: IL1A IL1B IL1F10 IL1RAP IL1RN IRAK2 MYD88 PIK3R1 SIGIRR TICAM2 TOLLIP
Entrez ID		10525	3554
HPRD ID		03448	00994
Ensembl ID		ENSG00000149428	ENSG00000115594
Uniprot IDs		A0A384P5T6 A0A494C039 B3KXH0 B7Z602 B7Z766 Q6IN67 Q9Y4L1	B8ZZW4 P14778
PDB IDs			1G0Y 1IRA 1ITB 4DEP 4GAF
Enriched GO Terms of Interacting Partners?
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