SEC23A and WBP11

Data Source:
BioGRID (two hybrid)

		SEC23A	WBP11
Description		SEC23 homolog A, COPII coat complex component	WW domain binding protein 11
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Cytosol ER To Golgi Transport Vesicle Membrane Extrinsic Component Of Membrane COPII Vesicle Coat Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	GTPase Activator Activity Protein Binding Zinc Ion Binding	Single-stranded DNA Binding RNA Binding Protein Binding WW Domain Binding
	Biological Process	Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I Intracellular Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of GTPase Activity COPII Vesicle Coating Protein Localization To Plasma Membrane COPII-coated Vesicle Cargo Loading	MRNA Splicing, Via Spliceosome RRNA Processing MRNA Cis Splicing, Via Spliceosome
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) COPII-mediated vesicle transport MHC class II antigen presentation Cargo concentration in the ER Antigen Presentation: Folding, assembly and peptide loading of class I MHC	mRNA Splicing - Major Pathway
Drugs
Diseases		Cranio-lenticulo-sutural dysplasia (CLSD); Boyadjiev-Jabs syndrome
GWAS		Metabolite levels ( 23823483) Vitamin D levels ( 29343764)
Interacting Genes		35 interacting genes: BNIP3 CADPS CDK16 CDK18 CLEC17A DCTN1 DNM2 DTX2 ERGIC3 ERLIN1 FASLG FATE1 GJA8 GLRA2 HOMEZ MFF MIA2 MIA3 MINAR1 NDRG1 PIAS2 RNF19B SDCBP2 SEC16A SEC23B SEC23IP SEC24B SEC24C SEC24D SF1 SLC7A1 SUCLA2 TMEM45B TNFSF14 WBP11	32 interacting genes: APBB1 ARF1 C5orf22 CD2BP2 CTNNBL1 DDX17 DDX5 FYN GIGYF2 GRB2 ITSN1 MCRS1 MORN4 NCK2 NOD2 PIK3R1 PPP1CA PPP1CB PPP1CC PQBP1 PRPF40A RBM5 RTN4IP1 RUNX1T1 SEC23A SRC TESC TRAF4 TRIP10 UBASH3A VIM WBP4
Entrez ID		10484	51729
HPRD ID		06714	18293
Ensembl ID		ENSG00000100934	ENSG00000084463
Uniprot IDs		Q15436	A0A024RAW9 Q9Y2W2
PDB IDs		2NUP 2NUT 2YRC 2YRD 3EFO 3EG9 3EGD 3EGX 5KYN 5KYU 5KYW 5KYX 5KYY 5VNE 5VNF 5VNG 5VNH 5VNI 5VNJ 5VNK 5VNL 5VNM 5VNN 5VNO
Enriched GO Terms of Interacting Partners?
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