ZNHIT1 and MAPK11

Data Source:
HPRD (two hybrid)

		ZNHIT1	MAPK11
Description		zinc finger HIT-type containing 1	mitogen-activated protein kinase 11
Image		No pdb structure
GO Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Nucleosome Binding Metal Ion Binding	Protein Serine/threonine Kinase Activity MAP Kinase Activity Protein Binding ATP Binding
	Biological Process	Histone Exchange	Activation Of MAPK Activity Protein Phosphorylation Ras Protein Signal Transduction Positive Regulation Of Gene Expression Positive Regulation Of Interleukin-12 Production Intracellular Signal Transduction Positive Regulation Of Erythrocyte Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Muscle Cell Differentiation Stress-activated MAPK Cascade Negative Regulation Of Cardiac Muscle Cell Proliferation Cellular Response To Interleukin-1 Cellular Response To Virus Regulation Of Signal Transduction By P53 Class Mediator
Pathways			NOD1/2 Signaling Pathway p38MAPK events p38MAPK events ERK/MAPK targets Activation of PPARGC1A (PGC-1alpha) by phosphorylation Oxidative Stress Induced Senescence DSCAM interactions VEGFA-VEGFR2 Pathway activated TAK1 mediates p38 MAPK activation Activation of the AP-1 family of transcription factors KSRP (KHSRP) binds and destabilizes mRNA Myogenesis Myogenesis RHO GTPases Activate NADPH Oxidases Regulation of TP53 Activity through Phosphorylation
Drugs			Minocycline KC706 Regorafenib
Diseases
GWAS			Acne (severe) ( 24927181) Adult body size ( 32376654)
Interacting Genes		22 interacting genes: BCL6 COL8A1 CSNK2B CYSRT1 DAPP1 FHL5 GOLGA6L9 GRB7 HINFP KANK2 KRTAP10-6 KRTAP10-7 KRTAP12-2 MAPK11 MAPK14 MAPK9 MDFI MYO5B OTX2 SH2D1A TNIP1 TP53	27 interacting genes: APP ATF2 BCL2 C9orf78 CCND1 CPNE6 DUSP10 DUSP16 EEF2K ELK1 ELK4 ESR2 HDAC3 HTRA2 JUN MAPKAPK5 MAPT MBP NOXA1 PML POLR3D PPM1D RPS6KA5 SH2D1A SOCS3 TAB1 ZNHIT1
Entrez ID		10467	5600
HPRD ID		15892	04208
Ensembl ID		ENSG00000106400	ENSG00000185386
Uniprot IDs		O43257	Q15759
PDB IDs			3GC8 3GC9 3GP0
Enriched GO Terms of Interacting Partners?
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