PIAS3 and SUMO3

Data Source:
BioGRID (pull down)

		PIAS3	SUMO3
Description		protein inhibitor of activated STAT 3	small ubiquitin like modifier 3
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GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Nuclear Speck Dendrite Synapse	Kinetochore Nucleus Nucleoplasm Cytoplasm PML Body
	Molecular Function	RNA Polymerase II Transcription Factor Binding Transcription Coregulator Activity Protein Binding Protein C-terminus Binding Zinc Ion Binding Potassium Channel Regulator Activity SUMO Transferase Activity Enzyme Binding Protein N-terminus Binding SUMO Ligase Activity	Protein Binding Protein Tag Ubiquitin-like Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Response To Hormone Positive Regulation Of Gene Expression Protein Sumoylation Negative Regulation Of Protein Sumoylation Positive Regulation Of Protein Sumoylation Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Membrane Potential TNFSF11-mediated Signaling Pathway	Protein Sumoylation Negative Regulation Of DNA Binding Regulation Of Protein Localization To Nucleus
Pathways		SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER	SUMO is conjugated to E1 (UBA2:SAE1) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is proteolytically processed SUMOylation of DNA damage response and repair proteins SUMOylation of transcription factors SUMOylation of transcription cofactors SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of DNA replication proteins SUMOylation of immune response proteins Formation of Incision Complex in GG-NER
Drugs
Diseases
GWAS			Delirium ( 29631748)
Interacting Genes		55 interacting genes: AR ATF7IP CARHSP1 CBS CREBBP CREM EP300 ESR1 ESR2 GEMIN4 GFI1 GLUL HABP4 HDAC1 HMGA2 MITF NCOA2 NR3C2 OPN1LW PGR PLIN3 PPP1CA PRPF40A PSMC1 RAC1 RELA REX1BD SATB1 SENP1 SERBP1 SERPINA10 SIAH1 SIAH2 SKIL SMAD2 SMAD3 SMAD4 SNAI2 SNIP1 SPOP SREBF2 STAT3 SUMO1 SUMO2 SUMO3 TBP TRIM27 TRIM32 TRIM55 TRIM63 UBA1 UBE2I ZFHX3 ZMIZ1 ZMIZ2	53 interacting genes: ANXA7 BLM CCNE2 CDKN1A CEBPA CHAF1A CUL3 DAXX EGLN3 FAM221A FOS HIPK2 HOMEZ HSF1 HSF2 JUN KALRN MAPKAPK3 PFDN1 PIAS1 PIAS2 PIAS3 PIAS4 PML RANGAP1 RNF111 RNF8 SAE1 SENP1 SENP2 SENP5 SMN1 SOX10 SOX6 SP100 TDG TDP2 TK1 TP53BP2 TTR UBA2 UBE2I UBE3A UPF2 USP25 USPL1 VIM WWTR1 YAP1 ZBTB33 ZBTB39 ZCCHC12 ZNF496
Entrez ID		10401	6612
HPRD ID		09068	03754
Ensembl ID		ENSG00000131788	ENSG00000184900
Uniprot IDs		B3KNI3 Q9Y6X2	P55854
PDB IDs		4MVT	1U4A 2IO1 2MP2 6K5R 6NNQ
Enriched GO Terms of Interacting Partners?
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