DLC1 and ZNF189

Data Source:
BioGRID (two hybrid)

		DLC1	ZNF189
Description		DLC1 Rho GTPase activating protein	zinc finger protein 189
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Caveola Focal Adhesion Cortical Actin Cytoskeleton Ruffle Membrane Membrane Raft	Nucleus
	Molecular Function	GTPase Activator Activity Protein Binding Lipid Binding SH2 Domain Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Neural Tube Closure Heart Morphogenesis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Signal Transduction Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Hindbrain Morphogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Forebrain Development Regulation Of Actin Cytoskeleton Organization Regulation Of Rho Protein Signal Transduction Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Protein Dephosphorylation Positive Regulation Of GTPase Activity Focal Adhesion Assembly Regulation Of Small GTPase Mediated Signal Transduction Negative Regulation Of Stress Fiber Assembly Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Execution Phase Of Apoptosis	Regulation Of Transcription By RNA Polymerase II
Pathways		Rho GTPase cycle	Generic Transcription Pathway
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Attention deficit hyperactivity disorder ( 30563984) Bipolar disorder ( 22688191) Emphysema imaging phenotypes ( 26030696) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Erosive tooth wear (severe vs non-severe) ( 29898447) Erosive tooth wear (severe vs none or mild) ( 29898447) Familial hepatitis B virus-related hepatocellular carcinoma ( 28662289) Fractional exhaled nitric oxide (childhood) ( 24315451) Gestational age at birth (child effect) ( 31194736) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Heel bone mineral density ( 30598549) Height ( 31562340) Intraocular pressure ( 29617998) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Late-onset Alzheimer's disease ( 27770636) Lung adenocarcinoma ( 28604730) Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Nose size ( 27182965) Obesity-related traits ( 23251661) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Percentage gas trapping ( 26030696) Platelet distribution width ( 32888494) PR interval ( 32439900) Refractive error ( 32231278) Smoking initiation (ever regular vs never regular) ( 31089300) Waist-hip ratio ( 28552196)
Interacting Genes		35 interacting genes: ACOT7 AKT1 AOPEP BAAT CCDC180 CDC14B CORO2A CTSV FANCC FBP2 HEMGN HSD17B3 MAPK3 PFKM PKM PPP3R2 PTEN RANGAP1 RASA1 RHOA RPS6KA1 SFRP4 SMAD1 STX17 TDRD7 TGFB1 TMEFF1 TMEM129 TMOD1 TNS2 TRMO USP4 XPA ZNF189 ZNF510	14 interacting genes: AURKA AXIN2 BMPR1A BRAF BUB1 CTNNA1 DLC1 ERBB2 KRAS MCC PMS2 SMAD4 SRC STK11
Entrez ID		10395	7743
HPRD ID		05035	11930
Ensembl ID		ENSG00000164741	ENSG00000136870
Uniprot IDs		A8K119 Q96QB1	A0A087X0K2 B7ZLK9 O75820
PDB IDs		2DKY 2GYT 2KAP 2LOZ 3KUQ 5FZT
Enriched GO Terms of Interacting Partners?
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