PCGF3 and PHC1

Data Source:
BioGRID (two hybrid)

		PCGF3	PHC1
Description		polycomb group ring finger 3	polyhomeotic homolog 1
Image		No pdb structure
GO Annotations	Cellular Component	X Chromosome Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	Protein Binding Metal Ion Binding	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Histone H2A-K119 Monoubiquitination Inactivation Of X Chromosome By Genetic Imprinting	Multicellular Organism Development Histone Ubiquitination Negative Regulation Of Transcription, DNA-templated Negative Regulation Of G0 To G1 Transition
Pathways			Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		General cognitive ability ( 29844566) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Heel bone mineral density ( 30598549) Hemostatic factors and hematological phenotypes ( 22443383) Intelligence (MTAG) ( 29326435) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Type 2 diabetes ( 30297969 32499647) White blood cell count ( 32888494 27863252)	Antisaccade task score ( 31596458) Cholesterol, total ( 24097068) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Height ( 31562340) Prepulse inhibition of the startle response ( 31596458) Small cell lung carcinoma ( 28604730) Total cholesterol levels ( 28334899)
Interacting Genes		15 interacting genes: BCOR BCORL1 BMI1 CBX6 DZIP3 HNRNPK PHC1 PHC2 RING1 RNF2 TRIM55 TRIM63 TRIM9 UBE2C UBE2D3	24 interacting genes: BMI1 FAM9A GMNN HSPA8 PCGF2 PCGF3 PHC2 PIAS2 PPP1CA PPP1CC RING1 RNF2 RNF4 SCMH1 SDCBP2 SFMBT1 SFMBT2 SIAH1 SP100 SUMO1 SUMO1P1 TET2 UBE2I ZCCHC7
Entrez ID		10336	1911
HPRD ID		11515	16009
Ensembl ID		ENSG00000185619	ENSG00000111752
Uniprot IDs		B3KQ06 B3KWT8 B4DTN5 Q3KNV8	P78364 Q6GMQ3 Q6N083
PDB IDs			2L8E
Enriched GO Terms of Interacting Partners?
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