LAMC3 and FRAT1

Data Source:
BioGRID (two hybrid)

		LAMC3	FRAT1
Description		laminin subunit gamma 3	FRAT regulator of WNT signaling pathway 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Basement Membrane Membrane Extracellular Matrix	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Structural Molecule Activity	Protein Binding
	Biological Process	Visual Perception Animal Organ Morphogenesis Tissue Development Astrocyte Development Cell Migration Extracellular Matrix Organization Substrate Adhesion-dependent Cell Spreading Retina Development In Camera-type Eye	Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Disassembly
Pathways		Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions MET activates PTK2 signaling	Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Alcohol consumption (max-drinks) ( 29460428) Deep ovarian and/or rectovaginal disease with dense adhesions ( 28333195) Degraded stimulus continuous performance test score ( 31596458) Endometriosis ( 28333195) Oral cavity and pharyngeal cancer ( 27749845) Oral cavity cancer ( 27749845) Smoking status (heavy vs never) ( 26423011)	Lymphocyte counts ( 32888494) Monocyte count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: ANXA5 CFB CRP CSNK2A2 CWC25 CYP2E1 EPB41L4B FRAT1 HP KIF1C LGMN NR1H2 PELI2 POT1 RPL35 SERPINA3 SLC43A3 TF YTHDC1 ZNF160	13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7
Entrez ID		10319	10023
HPRD ID		05069	03935
Ensembl ID		ENSG00000050555	ENSG00000165879
Uniprot IDs		Q8N2D6 Q9Y6N6	Q92837
PDB IDs			1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?
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