TCIRG1 and DNAH3

Data Source:
BioGRID (affinity chromatography technology)

		TCIRG1	DNAH3
Description		T cell immune regulator 1, ATPase H+ transporting V0 subunit a3	dynein axonemal heavy chain 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Vacuolar Proton-transporting V-type ATPase, V0 Domain Nucleus Lysosomal Membrane Late Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Phagocytic Vesicle Membrane Ficolin-1-rich Granule Membrane	Axonemal Dynein Complex Microtubule Dynein Complex
	Molecular Function	Transporter Activity Protein Binding Proton-transporting ATPase Activity, Rotational Mechanism ATPase Binding	Microtubule Motor Activity ATP Binding ATP-dependent Microtubule Motor Activity, Minus-end-directed Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Autophagosome Assembly Ossification Osteoclast Proliferation Cellular Calcium Ion Homeostasis Apoptotic Process Inflammatory Response Cellular Defense Response Vacuolar Acidification Protein Catabolic Process In The Vacuole Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Regulation Of Proton Transport Response To Silver Ion Gene Expression Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Macroautophagy Optic Nerve Development Establishment Of Cell Polarity B Cell Differentiation T Cell Differentiation Osteoclast Differentiation Ruffle Organization Protein Localization To Organelle Transferrin Transport Ion Transmembrane Transport Memory T Cell Activation T-helper 1 Cell Activation T Cell Homeostasis Neutrophil Degranulation Tooth Eruption Bone Resorption Regulation Of Osteoblast Differentiation Regulation Of Insulin Secretion Establishment Of Vesicle Localization Retina Development In Camera-type Eye Hematopoietic Stem Cell Homeostasis Enamel Mineralization Cellular Response To Cytokine Stimulus Phagosome Acidification Dentin Mineralization Proton Transmembrane Transport	Microtubule-based Movement Cilium-dependent Cell Motility
Pathways		ROS and RNS production in phagocytes Neutrophil degranulation Insulin receptor recycling Transferrin endocytosis and recycling Amino acids regulate mTORC1 Ion channel transport
Drugs		Tiludronic acid
Diseases		Osteopetrosis, including: Osteopetrosis, severe neonatal or infantile forms; Osteopetrosis, intermediate forms; Osteopetrosis with renal tubular acidosis; Osteopetrosis, late-onset form type 1; Osteopetrosis, late-onset form type 2; Osteopetrosis, osteoclast poor
GWAS		Heel bone mineral density ( 30598549) Reticulocyte count ( 32888494)	Diastolic blood pressure ( 27841878) Eosinophil counts ( 32888494) Immune reponse to smallpox (secreted IL-10) ( 22610502) Plateletcrit ( 32888494) Resting-state electroencephalogram vigilance ( 29703947) Serum uric acid levels ( 29559957) Systolic blood pressure ( 27841878)
Interacting Genes		6 interacting genes: CYTH2 KCNK1 MTDH POGZ TERF1 TLX3
Entrez ID		10312	55567
HPRD ID		05207	04513
Ensembl ID		ENSG00000110719	ENSG00000158486
Uniprot IDs		A0A024R5E5 Q13488	B4E1S1 Q8TD57
PDB IDs
Enriched GO Terms of Interacting Partners?
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