SNAPC5 and BRCC3

Data Source:
HPRD (two hybrid)

		SNAPC5	BRCC3
Description		small nuclear RNA activating complex polypeptide 5	BRCA1/BRCA2-containing complex subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Nuclear Body	Ubiquitin Ligase Complex Nuclear Ubiquitin Ligase Complex Spindle Pole Nucleus Nucleoplasm Cytoplasm Cytosol BRCA1-A Complex BRISC Complex
	Molecular Function	RNA Polymerase III General Transcription Initiation Factor Activity Protein Binding RNA Polymerase II General Transcription Initiation Factor Activity	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Metallopeptidase Activity Enzyme Regulator Activity Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding Lys63-specific Deubiquitinase Activity Isopeptidase Activity
	Biological Process	Transcription Initiation From RNA Polymerase III Promoter SnRNA Transcription By RNA Polymerase II SnRNA Transcription By RNA Polymerase III	Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining Cell Cycle Response To X-ray Response To Ionizing Radiation Protein Deubiquitination Protein Phosphopantetheinylation Positive Regulation Of DNA Repair Regulation Of Catalytic Activity Cell Division Protein K63-linked Deubiquitination Histone H2A K63-linked Deubiquitination Signal Transduction Involved In G2 DNA Damage Checkpoint
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes RNA Polymerase III Abortive And Retractive Initiation RNA Polymerase III Transcription Initiation From Type 3 Promoter RNA Polymerase III Transcription Initiation From Type 3 Promoter	Metalloprotease DUBs Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends G2/M DNA damage checkpoint
Drugs			Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS			Venous thromboembolism ( 31676865)
Interacting Genes		42 interacting genes: AMOT ARHGEF38 BATF BFSP2 BLOC1S1 BRCC3 CBY2 CCDC196 CDCA8 CREB5 CYTH1 CYTH4 DDIT3 EMILIN1 FAM9C GALR1 GORAB GRIPAP1 HMG20B ITGB3BP JUN LMO2 MBD3L1 MCRS1 MYF5 NDEL1 NMI NOL4 NUDT10 NUP62 POLR2J RNF4 S100Z SNAPC1 SNAPC4 STMN4 TRAPPC2 TRAPPC2B TXLNB ZNF177 ZNF559-ZNF177 ZNRD2	11 interacting genes: ANKRD11 BRCA1 FANCG IFNAR1 NUMA1 SHMT2 SNAPC5 SUMO2 UBC UBE2D1 UIMC1
Entrez ID		10302	79184
HPRD ID		16183	06465
Ensembl ID		ENSG00000174446	ENSG00000185515
Uniprot IDs		A0A024R5X1 O75971	P46736
PDB IDs			6H3C 6R8F
Enriched GO Terms of Interacting Partners?
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