CDKN1C and CCNE2

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CDKN1C	CCNE2
Description		cyclin dependent kinase inhibitor 1C	cyclin E2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Centrosome Cytosol Cyclin E1-CDK2 Complex Cyclin E2-CDK2 Complex
	Molecular Function	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein-containing Complex Binding	Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Cell Cycle Arrest Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Kinase Activity Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Epithelial Cell Proliferation Negative Regulation Of Cyclin-dependent Protein Kinase Activity	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Telomere Maintenance DNA Replication Initiation Homologous Chromosome Pairing At Meiosis Mitotic Cell Cycle Phase Transition Cell Division Regulation Of Cellular Protein Localization
Pathways		Cyclin D associated events in G1 Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)	G0 and Early G1 SCF(Skp2)-mediated degradation of p27/p21 DNA Damage/Telomere Stress Induced Senescence Association of TriC/CCT with target proteins during biosynthesis TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest CDK-mediated phosphorylation and removal of Cdc6 Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs
Diseases		Beckwith-Wiedemann syndrome Adrenal carcinoma	Laryngeal cancer Gastric cancer
GWAS		Birth weight ( 31043758) Calcium levels ( 20705733) Malaria ( 31844061)
Interacting Genes		10 interacting genes: AKT1 CCNE2 CDK4 FBXL12 LIMK1 MYOD1 NR4A2 PCNA RB1 SKP2	12 interacting genes: APP CDK2 CDK3 CDKN1A CDKN1B CDKN1C FBXO7 FBXW7 ORC3 SUMO2 SUMO3 ZDHHC17
Entrez ID		1028	9134
HPRD ID		02913	04801
Ensembl ID		ENSG00000129757	ENSG00000175305
Uniprot IDs		P49918	A0A024R9B0 O96020
PDB IDs
Enriched GO Terms of Interacting Partners?
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