UBE4B and PGAM5

Data Source:
BioGRID (enzymatic study)

		UBE4B	PGAM5
Description		ubiquitination factor E4B	PGAM family member 5, mitochondrial serine/threonine protein phosphatase
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GO Annotations	Cellular Component	Ubiquitin Ligase Complex Nucleus Cytoplasm	Mitochondrion Mitochondrial Outer Membrane Integral Component Of Membrane
	Molecular Function	Enzyme Binding Ubiquitin-ubiquitin Ligase Activity ATPase Binding	Protein Serine/threonine Phosphatase Activity GTPase Activator Activity Protein Binding Phosphatase Activity Protein-containing Complex Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Granzyme-mediated Apoptotic Signaling Pathway Response To UV Ubiquitin-dependent ERAD Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Protein Dephosphorylation Macroautophagy Positive Regulation Of GTPase Activity Necroptotic Process Negative Regulation Of Cold-induced Thermogenesis
Pathways
Drugs
Diseases
GWAS		Atrial fibrillation ( 29892015) Hepatocellular carcinoma ( 20676096) Resting heart rate ( 27798624)	Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		22 interacting genes: ATXN3 CASP3 CASP6 CASP7 CDKN2A DNAJC7 ESR1 FEZ1 GZMB HGS HRAS MAPK3 OTUB1 PGAM5 PPP3CA PRMT1 RAD23A TRIP12 UBE2D2 UBE2D3 VAV2 VCP	30 interacting genes: HSPA1B MIR106A MIR106B MIR107 MIR10B MIR128-1 MIR141 MIR145 MIR15A MIR16-1 MIR18B MIR200B MIR205 MIR206 MIR20B MIR21 MIR214 MIR25 MIR34A MIR451A MIR93 MIRLET7A1 MIRLET7A2 MIRLET7B MIRLET7E MIRLET7F1 SETDB1 UBE4B YWHAG ZBTB16
Entrez ID		10277	192111
HPRD ID		11659	14681
Ensembl ID		ENSG00000130939	ENSG00000247077
Uniprot IDs		O95155	Q96HS1
PDB IDs		2KRE 3L1X 3L1Z 5O75	3MXO 3O0T 5MUF 6CNI 6CNL
Enriched GO Terms of Interacting Partners?
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