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TRIM28 and RFC4
Data Source:
BioGRID
(pull down)
TRIM28
RFC4
Description
tripartite motif containing 28
replication factor C subunit 4
Image
GO Annotations
Cellular Component
Chromatin
Euchromatin
Heterochromatin
Nucleus
Nucleoplasm
Protein-containing Complex
RNA Polymerase II Transcription Regulator Complex
Nucleus
Nucleoplasm
DNA Replication Factor C Complex
Ctf18 RFC-like Complex
Elg1 RFC-like Complex
Molecular Function
DNA Binding
Chromatin Binding
Transcription Coactivator Activity
Transcription Corepressor Activity
RNA Binding
Protein Kinase Activity
Ubiquitin-protein Transferase Activity
Protein Binding
Zinc Ion Binding
SUMO Transferase Activity
Ubiquitin Protein Ligase Binding
Krueppel-associated Box Domain Binding
Chromo Shadow Domain Binding
Promoter-specific Chromatin Binding
DNA Clamp Loader Activity
Protein Binding
ATP Binding
Single-stranded DNA Helicase Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Epithelial To Mesenchymal Transition
DNA Repair
Chromatin Organization
Transcription Initiation From RNA Polymerase II Promoter
Ras Protein Signal Transduction
Embryo Implantation
Viral Process
Protein Ubiquitination
Protein Sumoylation
Positive Regulation Of Protein Import Into Nucleus
DNA Methylation Involved In Embryo Development
Positive Regulation Of DNA Binding
Innate Immune Response
Positive Regulation Of DNA Repair
Negative Regulation Of Single Stranded Viral RNA Replication Via Double Stranded DNA Intermediate
Negative Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription, DNA-templated
Protein Autophosphorylation
Convergent Extension Involved In Axis Elongation
Embryonic Placenta Morphogenesis
Positive Regulation Of DNA Methylation-dependent Heterochromatin Assembly
Negative Regulation Of DNA Demethylation
Negative Regulation Of Viral Release From Host Cell
Regulation Of Genetic Imprinting
DNA Replication
DNA-dependent DNA Replication
DNA Strand Elongation Involved In DNA Replication
DNA Repair
Transcription-coupled Nucleotide-excision Repair
Nucleotide-excision Repair, DNA Incision, 5'-to Lesion
Nucleotide-excision Repair, DNA Gap Filling
Translesion Synthesis
Telomere Maintenance Via Semi-conservative Replication
DNA Duplex Unwinding
Nucleotide-excision Repair, DNA Incision
Error-prone Translesion Synthesis
DNA Damage Response, Detection Of DNA Damage
Error-free Translesion Synthesis
Positive Regulation Of DNA-directed DNA Polymerase Activity
Regulation Of Signal Transduction By P53 Class Mediator
Pathways
Generic Transcription Pathway
SUMOylation of transcription cofactors
HCMV Early Events
Translesion synthesis by REV1
Recognition of DNA damage by PCNA-containing replication complex
Translesion Synthesis by POLH
Polymerase switching on the C-strand of the telomere
Activation of ATR in response to replication stress
PCNA-Dependent Long Patch Base Excision Repair
Translesion synthesis by POLK
Translesion synthesis by POLI
Termination of translesion DNA synthesis
HDR through Single Strand Annealing (SSA)
HDR through Homologous Recombination (HRR)
Processing of DNA double-strand break ends
Presynaptic phase of homologous DNA pairing and strand exchange
Gap-filling DNA repair synthesis and ligation in GG-NER
Dual Incision in GG-NER
Dual incision in TC-NER
Gap-filling DNA repair synthesis and ligation in TC-NER
Regulation of TP53 Activity through Phosphorylation
Polymerase switching
G2/M DNA damage checkpoint
Drugs
Diseases
GWAS
Mean corpuscular hemoglobin (
32888494
)
Activated partial thromboplastin time (
22703881
)
Interacting Genes
76 interacting genes:
CBX1
CBX3
CBX5
CDC34
CDC42
CDCA4
CDKN2A
CEBPB
CHAF1A
CHD3
ESR1
FBP1
FES
HDAC10
HTRA2
IRF1
IRF7
LYN
MAGEA2
MAGEA2B
MAGEA6
MAGED1
MAPKAPK2
MCM3
MCM5
MCM6
MYB
NPM1
NR3C1
NR4A1
NR4A3
NSMCE3
PCNA
PFDN5
PPP2CA
PTEN
RFC4
RNF4
SERTAD1
SERTAD2
SETDB1
SIN3A
SIRT1
SKI
SMARCAD1
SPG7
STAT3
SUMO2
TP73
TRIM24
TWIST1
UBE2C
UBE2D1
UBE2D2
UBE2D3
UBE2E1
UBE2E2
UBE2H
UBE2I
UBE2L3
UBE2N
UBE2U
VHL
VIM
YWHAQ
ZNF10
ZNF133
ZNF140
ZNF197
ZNF354A
ZNF382
ZNF420
ZNF496
ZNF689
ZNF74
ZNF93
13 interacting genes:
BRD4
CDK4
CHTF18
HDAC1
PCNA
PTEN
RAD17
RFC2
RFC3
RFC5
RNF41
SUMO2
TRIM28
Entrez ID
10155
5984
HPRD ID
03445
00022
Ensembl ID
ENSG00000130726
ENSG00000163918
Uniprot IDs
Q13263
P35249
PDB IDs
1FP0
2RO1
2YVR
6H3A
6I9H
6QAJ
6QU1
6VVO
Enriched GO Terms of Interacting Partners
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