PLXNC1 and SEMA7A

Data Source:
HPRD (in vivo, in vitro)

		PLXNC1	SEMA7A
Description		plexin C1	semaphorin 7A (John Milton Hagen blood group)
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GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Membrane	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Membrane Anchored Component Of Membrane Collagen-containing Extracellular Matrix
	Molecular Function	Signaling Receptor Binding Protein Binding Semaphorin Receptor Activity	Integrin Binding Protein Binding Semaphorin Receptor Binding Chemorepellent Activity
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Osteoblast Differentiation Neural Crest Cell Migration Positive Regulation Of Protein Phosphorylation Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Axon Guidance Olfactory Lobe Development Positive Regulation Of Cell Migration Positive Regulation Of Axon Extension Axon Extension Negative Regulation Of Axon Extension Involved In Axon Guidance Regulation Of Inflammatory Response Negative Chemotaxis Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Semaphorin-plexin Signaling Pathway
Pathways		Other semaphorin interactions	Other semaphorin interactions Other semaphorin interactions
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31959851 32296059) Blood protein levels ( 30072576 29875488 28240269) Diastolic blood pressure ( 30578418) Major depressive disorder ( 29317602) Multiple sclerosis ( 31604244) Pulse pressure ( 30578418) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)	Airflow obstruction ( 22837378) Alcohol consumption (drinks per week) ( 30643258) Apolipoprotein A1 levels ( 32203549) Craniofacial microsomia ( 26853712) HDL cholesterol levels ( 32203549) Hypertension ( 31879980)
Interacting Genes		1 interacting genes: SEMA7A	1 interacting genes: PLXNC1
Entrez ID		10154	8482
HPRD ID		05036	07081
Ensembl ID		ENSG00000136040	ENSG00000138623
Uniprot IDs		O60486	B3KMH6 F5GYX3 O75326
PDB IDs		3KUZ 3NVN 3NVQ 6VXK	3NVQ
Enriched GO Terms of Interacting Partners?
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