PLXNC1 and CKAP4

Data Source:
BioGRID (affinity chromatography technology)

		PLXNC1	CKAP4
Description		plexin C1	cytoskeleton associated protein 4
Image			No pdb structure
GO Annotations	Cellular Component	Semaphorin Receptor Complex Plasma Membrane Integral Component Of Plasma Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Lipid Droplet Cytosol Cytoskeleton Plasma Membrane Membrane Integral Component Of Membrane Nuclear Speck Azurophil Granule Membrane Specific Granule Membrane Cytoplasmic Ribonucleoprotein Granule Lamellar Body Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Semaphorin Receptor Activity	RNA Binding
	Biological Process	Cell Adhesion Negative Regulation Of Cell Adhesion Regulation Of Cell Shape Regulation Of Cell Migration Regulation Of GTPase Activity Positive Regulation Of Axonogenesis Semaphorin-plexin Signaling Pathway Involved In Axon Guidance	Neutrophil Degranulation Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Other semaphorin interactions	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Surfactant metabolism Neutrophil degranulation Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Asthma ( 31959851 32296059) Blood protein levels ( 30072576 29875488 28240269) Diastolic blood pressure ( 30578418) Major depressive disorder ( 29317602) Multiple sclerosis ( 31604244) Pulse pressure ( 30578418) Remission after SSRI treatment in MDD or neuroticism ( 29559929) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309) Response to ranibizumab in age-related macular degeneration (exudative) ( 30054556)	Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Metabolite levels ( 23823483) Refractive error ( 32231278)
Interacting Genes		1 interacting genes: SEMA7A	13 interacting genes: ASCC2 ATF4 DKK1 HAMP LINC01554 MLH1 MVP NDUFB7 NKX3-1 PLAT THOC7 TSNAX WASHC3
Entrez ID		10154	10970
HPRD ID		05036	16717
Ensembl ID		ENSG00000136040	ENSG00000136026
Uniprot IDs		O60486	A0A024RBH2 Q07065
PDB IDs		3KUZ 3NVN 3NVQ 6VXK
Enriched GO Terms of Interacting Partners?
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