OPTN and TBC1D17

Data Source:
BioGRID (two hybrid, proximity labelling technology, two hybrid, affinity chromatography technology, pull down)
HPRD (two hybrid)

		OPTN	TBC1D17
Description		optineurin	TBC1 domain family member 17
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Nucleoplasm Cytoplasm Autophagosome Golgi Apparatus Trans-Golgi Network Cytosol Perinuclear Region Of Cytoplasm Recycling Endosome Membrane	Autophagosome Cytosol Recycling Endosome
	Molecular Function	Protein Binding Protein C-terminus Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Polyubiquitin Modification-dependent Protein Binding Identical Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	GTPase Activator Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Receptor Recycling Autophagy Golgi Organization Signal Transduction Cell Death Positive Regulation Of Autophagy Viral Process Protein Localization To Golgi Apparatus Cellular Response To Unfolded Protein Golgi To Plasma Membrane Protein Transport Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Defense Response To Gram-negative Bacterium Parkin-mediated Stimulation Of Mitophagy In Response To Mitochondrial Depolarization Golgi Ribbon Formation Positive Regulation Of Xenophagy	Intracellular Protein Transport Autophagy Retrograde Transport, Endosome To Golgi Activation Of GTPase Activity Regulation Of Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition TBC/RABGAPs	TBC/RABGAPs
Drugs
Diseases		Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease Primary open angle glaucoma
GWAS		Cerebrospinal fluid p-tau levels ( 29274321) Cerebrospinal fluid p-tau levels in mild cognitive impairment ( 29274321) Paget's disease ( 21623375 20436471)
Interacting Genes		69 interacting genes: AIMP1 ARRDC3 ATG16L1 ATG5 CALM1 CCDC13 CDC23 CLTC CMYA5 DAZAP2 DYSF DZIP1 FAM189A2 FLII FOS FTH1 GABARAP GABARAPL1 GABARAPL2 GNAS GRM1 GTF3A HACE1 HSF2BP HSPB1 HTT IRAK1 KANSL1L LITAF LNX2 MAP1LC3A MAP1LC3C MPP1 MYH3 MYO6 PIAS4 PICK1 POU6F2 RAB11A RAB11B RAB12 RAB14 RAB25 RAB8A RBM12 RFFL RNF11 RNF216 SDCBP SLF2 SNX6 TBC1D15 TBC1D17 TNIP1 UBB UBC UQCRQ USP2 VCP WASHC3 WIPI2 ZNF17 ZNF181 ZNF302 ZNF329 ZNF398 ZNF426 ZNF670 ZNF711	19 interacting genes: ASCC2 CALCOCO1 CCT5 CDKN2D DHX29 FBL GABARAPL1 GPS1 GTF3C1 MAP1LC3A MAP1LC3B NIPSNAP1 OPTN RAB1A RAB5A RAB5B RAB5C SLC1A5 TAX1BP1
Entrez ID		10133	79735
HPRD ID		03891	15471
Ensembl ID		ENSG00000123240	ENSG00000104946
Uniprot IDs		Q96CV9	Q9HA65
PDB IDs		2LO4 2LUE 3VTV 3VTW 5AAZ 5B83 5EOA 5EOF
Enriched GO Terms of Interacting Partners?
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