TRAP1 and IFT140

Data Source:
BioGRID (proximity labelling technology)

		TRAP1	IFT140
Description		TNF receptor associated protein 1	intraflagellar transport 140
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Mitochondrial Matrix Membrane	Photoreceptor Outer Segment Centrosome Centriole Cilium Axoneme Intraciliary Transport Particle A Photoreceptor Connecting Cilium Ciliary Basal Body Ciliary Tip
	Molecular Function	RNA Binding Tumor Necrosis Factor Receptor Binding Protein Binding ATP Binding Protein Kinase Binding Unfolded Protein Binding	Molecular_function Protein Binding
	Biological Process	Protein Folding Translational Attenuation Chaperone-mediated Protein Folding Negative Regulation Of Cellular Respiration Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To Hydrogen Peroxide	Determination Of Left/right Symmetry Heart Development Regulation Of Smoothened Signaling Pathway Neural Tube Patterning Embryonic Camera-type Eye Development Intraciliary Retrograde Transport Intraciliary Transport Involved In Cilium Assembly Photoreceptor Cell Outer Segment Organization Intraciliary Transport Embryonic Digit Morphogenesis Embryonic Cranial Skeleton Morphogenesis Cilium Assembly Protein Localization To Cilium Regulation Of Cilium Assembly Non-motile Cilium Assembly Embryonic Brain Development
Pathways		Respiratory electron transport	Hedgehog 'off' state Intraflagellar transport
Drugs
Diseases
GWAS		Asthma ( 32296059) Estimated glomerular filtration rate ( 31152163 31451708) Granulocyte count ( 27863252) Infliximab-induced mucosal healing in Crohn's disease ( 31039275) Metabolite levels (HVA/5-HIAA ratio) ( 23319000) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) White blood cell count ( 32888494 27863252)	Coronary artery disease ( 29212778 33020668) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383)
Interacting Genes		16 interacting genes: APP ESX1 EXT1 EXT2 HGS MCPH1 PSMC4 PTGER4 RB1 SMAD4 TGFBR1 TGFBR2 TLR1 TLR6 TNFRSF1A TPM3	5 interacting genes: CELSR3 CRK NEK2 PFDN1 RANBP2
Entrez ID		10131	9742
HPRD ID		05868	11093
Ensembl ID		ENSG00000126602	ENSG00000187535
Uniprot IDs		A0A140VJY2 Q12931 Q53FS6	Q96RY7
PDB IDs		4Z1F 4Z1G 4Z1H 4Z1I 5F3K 5F5R 5HPH 5Y3N 5Y3O 6XG6 7C04 7C05
Enriched GO Terms of Interacting Partners?
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