LRPPRC and MIR145

Data Source:
BioGRID (unspecified method)

		LRPPRC	MIR145
Description		leucine rich pentatricopeptide repeat containing	microRNA 145
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Nucleus Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Mitochondrion Cytoskeleton Microtubule Membrane Mitochondrial Nucleoid Perinuclear Region Of Cytoplasm Ribonucleoprotein Complex	Extracellular Exosome
	Molecular Function	Single-stranded DNA Binding RNA Binding Protein Binding Microtubule Binding Ubiquitin Protein Ligase Binding Beta-tubulin Binding Actin Filament Binding	RNA Polymerase II Complex Binding MRNA 3'-UTR Binding MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Negative Regulation Of Mitochondrial RNA Catabolic Process Mitochondrion Transport Along Microtubule MRNA Transport Regulation Of Mitochondrial Translation	Regulation Of Smooth Muscle Contraction Negative Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Ectodermal Cell Differentiation Positive Regulation Of Fibroblast Migration Negative Regulation Of Angiogenesis Actin Cytoskeleton Organization Negative Regulation Of Cell Migration Negative Regulation Of Interleukin-16 Production Positive Regulation Of Interleukin-10 Production Regulation Of Collagen Biosynthetic Process Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Vascular Associated Smooth Muscle Cell Differentiation Myofibroblast Differentiation Angiotensin-activated Signaling Pathway Positive Regulation Of Macrophage Activation Establishment Or Maintenance Of Cell Type Involved In Phenotypic Switching Positive Regulation Of Macrophage Differentiation Mesodermal Cell Differentiation Negative Regulation Of Smooth Muscle Cell Proliferation Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Kinase B Signaling Aorta Smooth Muscle Tissue Morphogenesis Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Canonical Wnt Signaling Pathway Regulation Of Phenotypic Switching Negative Regulation Of Somatic Stem Cell Population Maintenance Negative Regulation Of Somatic Stem Cell Division Negative Regulation Of Vascular Associated Smooth Muscle Cell Dedifferentiation Positive Regulation Of Cardiac Vascular Smooth Muscle Cell Differentiation
Pathways		TP53 Regulates Metabolic Genes Respiratory electron transport
Drugs
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30679032) Bitter alcoholic beverage consumption ( 31046077) Chronotype ( 30696823) Hand grip strength ( 29691431 29313844) Levodopa-induced dyskinesia in levodopa treated Parkinson's disease ( 32733355) Medication use (calcium channel blockers) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Morning person ( 30696823) Refractive error ( 32231278) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		82 interacting genes: ANKRD1 CECR2 FOXO1 HEBP2 LINC01554 MAP1S MIR1-1 MIR1-2 MIR106A MIR106B MIR107 MIR10B MIR122 MIR128-1 MIR128-2 MIR138-1 MIR138-2 MIR140 MIR141 MIR143 MIR145 MIR155 MIR15A MIR15B MIR16-1 MIR16-2 MIR17 MIR18A MIR18B MIR199A1 MIR199A2 MIR19A MIR19B1 MIR19B2 MIR200A MIR200B MIR200C MIR205 MIR206 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR29B1 MIR29B2 MIR29C MIR31 MIR34A MIR34B MIR34C MIR363 MIR429 MIR451A MIR7-1 MIR7-2 MIR7-3 MIR9-1 MIR9-2 MIR9-3 MIR92A1 MIR92A2 MIR93 MIR98 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7G MIRLET7I NFKBIB PPARGC1A PTEN UXT	79 interacting genes: ADARB1 APOBEC3B AQR C1QBP DARS1 DDX1 DDX21 DDX3X DHX36 EIF2AK2 EPRS1 ERAL1 FAM98A FUS G3BP2 HARS2 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP6 LARP7 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI2 NONO NUDT16L1 NUDT21 PDCD11 PGAM5 PRMT1 PTBP1 PTBP3 PUF60 PUM1 RARS1 RBM14 RBM4 RTCA RTCB SF3A1 SF3A3 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SYNCRIP TAF15 TENT2 TIAL1 TRA2A TRA2B U2SURP UPF1 UTP20 YBX1 YBX3 ZFR ZNF346
Entrez ID		10128	406937
HPRD ID		06343
Ensembl ID		ENSG00000138095	ENSG00000276365
Uniprot IDs		E5KNY5 P42704
PDB IDs
Enriched GO Terms of Interacting Partners?
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