ABCF2 and HADHA

Data Source:
BioGRID (two hybrid)

		ABCF2	HADHA
Description		ATP binding cassette subfamily F member 2	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit alpha
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Mitochondrion Mitochondrial Inner Membrane Mitochondrial Fatty Acid Beta-oxidation Multienzyme Complex Mitochondrial Nucleoid
	Molecular Function	ATP Binding ATPase Activity	3-hydroxyacyl-CoA Dehydrogenase Activity Acetyl-CoA C-acetyltransferase Activity Enoyl-CoA Hydratase Activity Protein Binding Long-chain-3-hydroxyacyl-CoA Dehydrogenase Activity
	Biological Process		Fatty Acid Beta-oxidation Cardiolipin Acyl-chain Remodeling
Pathways			Acyl chain remodeling of CL Beta oxidation of myristoyl-CoA to lauroyl-CoA mitochondrial fatty acid beta-oxidation of unsaturated fatty acids Beta oxidation of palmitoyl-CoA to myristoyl-CoA Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA Beta oxidation of octanoyl-CoA to hexanoyl-CoA Beta oxidation of hexanoyl-CoA to butanoyl-CoA
Drugs			NADH
Diseases			Disorders of fatty-acid oxidation, including: Medium-chain (MC) acyl-CoA dehydrogenase (AD) deficiency (MCADD); Short-chain AD deficiency (SCADD) ; Short-branched-chain AD deficiency (SBCADD) ; Very long-chain AD deficiency (VLCADD) ; Long-chain 3-hydroxyacyl CoA dehydrogenase deficiency (LCHADD) ; Trifunctional protein deficiency (TFP); Carnitine palmitoyltransferase deficiency (CPT); Carnitine-acylcarnitine translocase deficiency (CACT); Systemic primary carnitine deficiency (CDSP) Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Eyebrow thickness ( 26926045) Femoral neck bone mineral density ( 22504420) Height ( 31562340) IgG glycosylation ( 23382691) IgG N-glycosylation phenotypes (multivariate analysis) ( 32128391) Pre-treatment viral load in HIV-1 infection ( 31219150)
Interacting Genes		4 interacting genes: ANKRD28 HADHA PTEN UPF2	8 interacting genes: ABCF2 ATXN2L CD74 HSD17B10 NR4A1 PIN1 PTEN YWHAQ
Entrez ID		10061	3030
HPRD ID		12403	02934
Ensembl ID		ENSG00000033050	ENSG00000084754
Uniprot IDs		A0A090N7X1 Q9UG63	E9KL44 P40939
PDB IDs			5ZQZ 5ZRV 6DV2
Enriched GO Terms of Interacting Partners?
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