HDAC5 and RUNX3

Data Source:
HPRD (in vitro, in vivo)

		HDAC5	RUNX3
Description		histone deacetylase 5	RUNX family transcription factor 3
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Chromatin Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Core-binding Factor Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Identical Protein Binding Histone Deacetylase Binding Metal Ion Binding Repressing Transcription Factor Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding ATP Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Chromatin Silencing Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Response To Drug Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation	Negative Regulation Of Transcription By RNA Polymerase II Ossification Chondrocyte Differentiation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Hemopoiesis Neuron Differentiation Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Cell Cycle Positive Regulation Of Transcription, DNA-templated Peripheral Nervous System Neuron Development Negative Regulation Of Epithelial Cell Proliferation Response To Transforming Growth Factor Beta
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription	Binding of TCF/LEF:CTNNB1 to target gene promoters RUNX3 regulates CDKN1A transcription RUNX3 regulates NOTCH signaling Regulation of RUNX3 expression and activity RUNX3 Regulates Immune Response and Cell Migration RUNX3 Regulates Immune Response and Cell Migration RUNX3 regulates WNT signaling RUNX3 regulates YAP1-mediated transcription RUNX3 regulates RUNX1-mediated transcription RUNX3 regulates p14-ARF RUNX3 regulates BCL2L11 (BIM) transcription
Drugs		Belinostat Panobinostat
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bipolar disorder ( 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549 28869591) Mean platelet volume ( 32888494)	Adverse response to drug ( 30420678) Albumin-globulin ratio ( 29403010) Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Ankylosing spondylitis ( 23749187 21743469) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 32296059 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) Celiac disease ( 22057235 20190752) Crohn's disease ( 23266558) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) IgA levels ( 28628107) Itch intensity from mosquito bite ( 28199695) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Lead levels ( 26025379) Lymphocyte counts ( 32888494) Male-pattern baldness ( 29146897 27182965 28196072) Monocyte count ( 32888494) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244) Non-albumin protein levels ( 29403010) Psoriasis ( 23143594) Psoriasis vulgaris ( 26626624) Response to protease inhibitor treatment in hepatitis c (peak serum total bilirubin levels) ( 24503447) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		61 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 LMO2 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	16 interacting genes: CBFB EP300 GUCD1 HDAC1 HDAC2 HDAC4 HDAC5 MYCN NOTCH1 SMAD3 SMURF1 SMURF2 SP110 TLE1 TP53 YAP1
Entrez ID		10014	864
HPRD ID		09246	02565
Ensembl ID		ENSG00000108840	ENSG00000020633
Uniprot IDs		Q9UQL6	A0A024RAH4 Q13761
PDB IDs		5UWI	5W69
Enriched GO Terms of Interacting Partners?
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