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KDM8

Description lysine demethylase 8
Image
GO Annotations Cellular Component
  • Nucleus
  • Nucleoplasm
  • Chromosome
  • Cytosol
Molecular Function
  • Chromatin Binding
  • Endopeptidase Activity
  • Aminopeptidase Activity
  • Protein Binding
  • 2-oxoglutarate-dependent Dioxygenase Activity
  • Methylated Histone Binding
  • Metal Ion Binding
  • Histone Demethylase Activity (H3-K36 Specific)
  • L-arginine 3-hydroxylase Activity
Biological Process
  • G2/M Transition Of Mitotic Cell Cycle
  • Proteolysis
  • Protein Destabilization
  • Circadian Regulation Of Gene Expression
  • Negative Regulation Of Transcription, DNA-templated
  • Positive Regulation Of Transcription, DNA-templated
  • Histone H3-K36 Demethylation
Pathways
Drugs
Diseases
GWAS
  • Asthma ( 31959851 31619474)
  • Gut microbiota (bacterial taxa) ( 27723756)
  • Night sleep phenotypes ( 27126917)
Novel Interacting Genes 1 novel interacting genes: DCTN5
Interacting Genes 6 interacting genes: DDIT4L IFT20 ISY1 MEOX2 NUBPL PCYT2
Entrez ID 79831
HPRD ID 07836
Ensembl ID ENSG00000155666
Uniprot IDs A0A0S2Z5P8 A0A0S2Z5T1 Q8N371
PDB IDs 3UYJ 4AAP 4GAZ 4GJY 4GJZ 4QU1 5FBJ 6AVS 6AX3 6F4M 6F4N 6F4O 6F4P 6F4Q 6F4R 6F4S 6F4T 6I9L 6I9M 6I9N
Enriched GO Terms of Interacting Partners?
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© Madhavi K. Ganapathiraju 2012-2025