MVP and PARP4

Number of citations of the paper that reports this interaction (PubMedID 28514442)
406

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid, in vitro)

		MVP	PARP4
Description		major vault protein	poly(ADP-ribose) polymerase family member 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Pore Cytoplasm Cytosol Cytoskeleton Membrane Secretory Granule Lumen Perinuclear Region Of Cytoplasm Extracellular Exosome Ficolin-1-rich Granule Lumen	Nucleus Cytoplasm Cytosol Spindle Microtubule Membrane Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Protein Kinase Binding Protein Phosphatase Binding Identical Protein Binding	DNA Binding NAD+ ADP-ribosyltransferase Activity Protein Binding Enzyme Binding Protein ADP-ribosylase Activity
	Biological Process	Protein Transport Negative Regulation Of Protein Autophosphorylation ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway MRNA Transport Negative Regulation Of Protein Tyrosine Kinase Activity	DNA Repair Cellular Protein Modification Process Protein ADP-ribosylation Inflammatory Response Cellular Response To DNA Damage Stimulus Cell Death Response To Xenobiotic Stimulus Regulation Of Telomerase Activity Protein Mono-ADP-ribosylation
Pathways		Neutrophil degranulation	Nicotinamide salvaging Maturation of nucleoprotein Maturation of nucleoprotein
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 34021172)	Idiopathic intracranial hypertension ( 29608535) Obesity-related traits ( 23251661) Sudden cardiac arrest ( 21658281)
Interacting Genes		68 interacting genes: ADAMTSL4 BANP C1orf94 CALCOCO2 CAMK2B CKAP4 DISC1 DLX2 DNAH5 DTX2 EPHX2 ESR1 FMR1 FNDC3B FXR1 FXR2 GIT2 GOLGA2 HP IHO1 KCTD9 KPNA2 KPNA3 MDFI MEOX1 MEOX2 MID2 MRTFA MT-CYB NNT NOTCH2NLA NRF1 NTAQ1 PARP4 PIH1D2 PLSCR1 POT1 PSTPIP1 PTEN PTPN11 RAB3IP RBPMS REL RHOXF2 RIMBP3 RNF111 SAXO1 SERTAD1 SKIL SLC2A4 STN1 TCF4 TENT5C TFCP2 TLE5 TOLLIP TP53 TRAF2 TRIM27 TRIM42 TRIP13 TRIP6 TSPOAP1 UBC UBTD2 VAC14 ZBTB32 ZMIZ2	4 interacting genes: CCT6A MVP SMAD3 TUBA3C
Entrez ID		9961	143
HPRD ID		05475	09598
Ensembl ID		ENSG00000013364	ENSG00000102699
Uniprot IDs		Q14764 X5D2M8 X5D7K9 X5DNU0	Q9UKK3
PDB IDs		1Y7X
Enriched GO Terms of Interacting Partners?
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