USP15 and UCHL3

Number of citations of the paper that reports this interaction (PubMedID 22626734)
6

Data Source:
BioGRID (enzymatic study)

		USP15	UCHL3
Description		ubiquitin specific peptidase 15	ubiquitin C-terminal hydrolase L3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Deubiquitinase Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Modification-dependent Histone Binding Lys48-specific Deubiquitinase Activity	Thiol-dependent Deubiquitinase Protein Binding Peptidase Activity NEDD8-specific Protease Activity Ubiquitin Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Transforming Growth Factor Beta Receptor Signaling Pathway Protein Deubiquitination BMP Signaling Pathway Monoubiquitinated Protein Deubiquitination Histone H2B Conserved C-terminal Lysine Deubiquitination Pathway-restricted SMAD Protein Phosphorylation Protein K48-linked Deubiquitination Positive Regulation Of RIG-I Signaling Pathway Negative Regulation Of Antifungal Innate Immune Response Protein K27-linked Deubiquitination	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Protein Deubiquitination Protein Catabolic Process Post-translational Protein Modification
Pathways		Downregulation of TGF-beta receptor signaling UCH proteinases Ub-specific processing proteases	UCH proteinases Synthesis of active ubiquitin: roles of E1 and E2 enzymes Neddylation
Drugs
Diseases
GWAS		Alopecia areata ( 25608926) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Plateletcrit ( 32888494 27863252) Pulmonary function decline ( 22424883) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271)	Diabetic retinopathy ( 23562823) Metabolite levels ( 23823483)
Interacting Genes		55 interacting genes: BAP1 BMI1 BMPR1A BRAP CARD9 CCDC57 CDK4 DDX58 FHL1 GEMIN4 GOLGA2 GOLGA6A H2BC21 IL1R2 JOSD1 KEAP1 MAD1L1 MDC1 MDM2 OTUB1 PHF7 PIBF1 PLA2G2A PRPF31 RBCK1 RNF126 RNF144B SENP3 SENP8 SMURF2 SPDL1 STAM STK33 SYVN1 TEX11 TRAF6 TRIM17 TRIM21 TRIM25 TRIM46 TRIM5 TRIM54 TRIM63 TRIM74 UCHL1 UCHL3 USP14 USP2 USP20 USP21 USP28 USP33 USP51 USP8 YOD1	22 interacting genes: ATM ATXN7L3 CDH1 FOXM1 LONRF1 NEDD8 NSG2 PJA1 PKD2 PLA2G2A POGK RAD51 TRIM27 TRIM54 TRIM55 TRIM63 UBC UBE2S USP15 USP21 USP28 XRCC5
Entrez ID		9958	7347
HPRD ID		05293	04367
Ensembl ID		ENSG00000135655	ENSG00000118939
Uniprot IDs		Q9Y4E8	A0A087WTB8 A0A140VJZ4 P15374
PDB IDs		1W6V 3LMN 3PPA 3PV1 3T9L 4A3O 4A3P 5JJW 6CPM 6CRN 6DJ9 6GH9 6GHA 6ML1	1UCH 1XD3 6ISU 6QML
Enriched GO Terms of Interacting Partners?
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