PAN2 and RBBP8

Number of citations of the paper that reports this interaction (PubMedID 33097710)
3

Data Source:
BioGRID (enzymatic study)

		PAN2	RBBP8
Description		poly(A) specific ribonuclease subunit PAN2	RB binding protein 8, endonuclease
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol PAN Complex	Nucleus Nucleoplasm Transcription Repressor Complex Site Of Double-strand Break Intracellular Membrane-bounded Organelle
	Molecular Function	3'-5'-exoribonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Thiol-dependent Deubiquitinase Protein Binding Metal Ion Binding	Single-stranded DNA Endodeoxyribonuclease Activity Y-form DNA Binding Double-strand/single-strand DNA Junction Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Corepressor Activity Protein Binding Identical Protein Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Flap-structured DNA Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination Blastocyst Hatching DNA Repair Regulation Of Transcription By RNA Polymerase II DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Response To Estradiol Negative Regulation Of Transcription, DNA-templated Cell Division Meiotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis
Pathways		Deadenylation of mRNA	HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function
Drugs
Diseases
GWAS		Axial length ( 24144296) Height ( 34054925 25429064) Refractive error ( 32231278)	Eosinophil percentage of white cells ( 27863252) Estradiol levels ( 34255042) Height ( 25429064 18391951) Hip circumference adjusted for BMI ( 34021172) Intracranial aneurysm ( 20364137) Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) ( 27418160) Late-onset myasthenia gravis ( 26562150) Lung function (FEV1) ( 30061609) Lymphocyte counts ( 32888494) Scalp hair shape ( 26926045) Tuberculosis ( 20694014) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		9 interacting genes: ATM DYNLL1 PABPC1 PAN3 RBBP8 RBCK1 RNF144B TNRC6A TRIM35	36 interacting genes: ATM BARD1 BRCA1 CLU CTBP1 CUL3 DNA2 FXR2 FZR1 HID1 IGFBP7 IKBKG IKZF1 IKZF3 KLHL15 LIMS1 LMO1 LMO2 LMO4 MAP2K4 NTAQ1 PAN2 PCNA PIN1 PRRG4 RAF1 RB1 RBL1 RBL2 RGS17 SIAH1 SIAH2 TGIF2 TMEM54 TOPBP1 USP4
Entrez ID		9924	5932
HPRD ID		15640	04990
Ensembl ID		ENSG00000135473	ENSG00000101773
Uniprot IDs		Q504Q3	A0A024RC34 Q99708
PDB IDs			2L4Z 4D2H
Enriched GO Terms of Interacting Partners?
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