PAN2 and TNRC6A

Number of citations of the paper that reports this interaction (PubMedID 21984185)
149

Data Source:
BioGRID (pull down)

		PAN2	TNRC6A
Description		poly(A) specific ribonuclease subunit PAN2	trinucleotide repeat containing adaptor 6A
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytosol PAN Complex	P-body Nucleoplasm Golgi Apparatus Cytosol RISC Complex Intracellular Membrane-bounded Organelle
	Molecular Function	3'-5'-exoribonuclease Activity Nucleic Acid Binding Poly(A)-specific Ribonuclease Activity Thiol-dependent Deubiquitinase Protein Binding Metal Ion Binding	RNA Binding Protein Binding
	Biological Process	Nuclear-transcribed MRNA Poly(A) Tail Shortening MRNA Processing Positive Regulation Of Cytoplasmic MRNA Processing Body Assembly RNA Phosphodiester Bond Hydrolysis, Exonucleolytic	Cellular Response To Starvation Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Positive Regulation Of Nuclear-transcribed MRNA Poly(A) Tail Shortening
Pathways		Deadenylation of mRNA	Pre-NOTCH Transcription and Translation Oxidative Stress Induced Senescence Oncogene Induced Senescence Ca2+ pathway Post-transcriptional silencing by small RNAs Transcriptional regulation by small RNAs TP53 Regulates Metabolic Genes MAPK6/MAPK4 signaling Transcriptional Regulation by VENTX Regulation of RUNX1 Expression and Activity RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Regulation of PTEN mRNA translation Competing endogenous RNAs (ceRNAs) regulate PTEN translation Transcriptional Regulation by MECP2 Transcriptional Regulation by MECP2 Estrogen-dependent gene expression Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs
Diseases
GWAS		Axial length ( 24144296) Height ( 34054925 25429064) Refractive error ( 32231278)	Adult body size ( 32376654) Age at first sexual intercourse ( 34211149) Alcohol consumption ( 31358974) Alcohol consumption (drinks per week) ( 30643258 30679032) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or high blood pressure (pleiotropy) ( 30940143) Experiencing mood swings ( 29500382) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Macular thickness ( 30535121) Mean platelet volume ( 32888494) Metabolic syndrome ( 31589552) Problematic alcohol use ( 32451486) Pulse pressure ( 27841878 27618448 30578418) Smoking initiation ( 33082346) Systolic blood pressure ( 27841878 27618448 30578418) Type 2 diabetes (dietary heme iron intake interaction) ( 23386860) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		9 interacting genes: ATM DYNLL1 PABPC1 PAN3 RBBP8 RBCK1 RNF144B TNRC6A TRIM35	7 interacting genes: AGO4 PAN2 SMARCB1 TRIM65 TRIP13 UBC WNK1
Entrez ID		9924	27327
HPRD ID		15640	11640
Ensembl ID		ENSG00000135473	ENSG00000090905
Uniprot IDs		Q504Q3	Q8NDV7
PDB IDs			5W6V
Enriched GO Terms of Interacting Partners?
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