ARHGEF17 and RAB14

		ARHGEF17	RAB14
Description		Rho guanine nucleotide exchange factor 17	RAB14, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Golgi Membrane Lysosome Lysosomal Membrane Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cilium Endomembrane System Trans-Golgi Network Transport Vesicle Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding
	Biological Process	Actin Cytoskeleton Organization Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction	Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Defense Response To Bacterium Regulation Of Embryonic Development Intracellular Transport Phagosome Maturation Phagolysosome Assembly Involved In Apoptotic Cell Clearance
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle	Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		FEV1 ( 30804560) GIP levels in response to oral glucose tolerance test (120 minutes) ( 29093273) Lung function (FEV1/FVC) ( 30804560) Peak expiratory flow ( 30804560) Refractive error ( 32231278)	Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)
Interacting Genes		3 interacting genes: OTX1 RAB14 RHOA	19 interacting genes: ADRB2 APP ARHGEF17 CHM EXOC5 FAM71C FGA GSN NR5A1 OCRL OPTN RAB11FIP5 RBSN RUFY1 SH3BP5L SMURF2 TLR4 TNC XRN2
Entrez ID		9828	51552
HPRD ID		10658	06693
Ensembl ID		ENSG00000110237	ENSG00000119396
Uniprot IDs		Q96PE2	A0A024R845 P61106
PDB IDs			1Z0F 4D0G 4DRZ
Enriched GO Terms of Interacting Partners?
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