RAB14 and GSN

		RAB14	GSN
Description		RAB14, member RAS oncogene family	gelsolin
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GO Annotations	Cellular Component	Golgi Membrane Lysosome Lysosomal Membrane Early Endosome Late Endosome Rough Endoplasmic Reticulum Golgi Stack Trans-Golgi Network Cytosol Plasma Membrane Cilium Endomembrane System Trans-Golgi Network Transport Vesicle Early Endosome Membrane Nuclear Outer Membrane-endoplasmic Reticulum Membrane Network Intracellular Membrane-bounded Organelle Phagocytic Vesicle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane Extracellular Exosome Tertiary Granule Membrane	Podosome Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Sarcoplasm Actin Cap Cortical Actin Cytoskeleton Secretory Granule Lumen Extracellular Exosome Blood Microparticle Ficolin-1-rich Granule Lumen
	Molecular Function	GTPase Activity Protein Binding GTP Binding GDP Binding Myosin V Binding	Actin Binding Calcium Ion Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol 3-kinase Catalytic Subunit Binding Myosin II Binding Actin Filament Binding
	Biological Process	Intracellular Protein Transport Golgi To Endosome Transport Fibroblast Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Endocytic Recycling Regulation Of Protein Localization Defense Response To Bacterium Regulation Of Embryonic Development Intracellular Transport Phagosome Maturation Phagolysosome Assembly Involved In Apoptotic Cell Clearance	Phagocytosis, Engulfment Central Nervous System Development Actin Polymerization Or Depolymerization Positive Regulation Of Gene Expression Striated Muscle Atrophy Extracellular Matrix Disassembly Cell Projection Assembly Actin Filament Polymerization Actin Filament Depolymerization Protein Destabilization Response To Muscle Stretch Sequestering Of Actin Monomers Actin Nucleation Negative Regulation Of Viral Entry Into Host Cell Actin Filament Severing Barbed-end Actin Filament Capping Positive Regulation Of Actin Nucleation Actin Filament Capping Relaxation Of Cardiac Muscle Cilium Assembly Regulation Of Podosome Assembly Cardiac Muscle Cell Contraction Actin Filament Reorganization Renal Protein Absorption Hepatocyte Apoptotic Process Positive Regulation Of Keratinocyte Apoptotic Process Regulation Of Establishment Of T Cell Polarity Regulation Of Plasma Membrane Raft Polarization Regulation Of Receptor Clustering Positive Regulation Of Protein Processing In Phagocytic Vesicle Amyloid Fibril Formation Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway
Pathways		Translocation of SLC2A4 (GLUT4) to the plasma membrane Synthesis of PIPs at the plasma membrane Neutrophil degranulation RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Caspase-mediated cleavage of cytoskeletal proteins Neutrophil degranulation Sensory processing of sound by outer hair cells of the cochlea Amyloid fiber formation
Drugs			Zinc Latrunculin A Copper Zinc acetate
Diseases
GWAS		Immune reponse to smallpox (secreted IFN-alpha) ( 22610502)	Blood protein levels ( 30072576)
Interacting Genes		19 interacting genes: ADRB2 APP ARHGEF17 CHM EXOC5 FAM71C FGA GSN NR5A1 OCRL OPTN RAB11FIP5 RBSN RUFY1 SH3BP5L SMURF2 TLR4 TNC XRN2	28 interacting genes: ACTA1 ACTB ACTG1 ACTN4 APP AR BCAR1 CASP3 CLIC5 CSK ERBB2 FHIT FN1 HSP90AA1 LIMK2 PIK3CG PLCG1 POLE3 PTK2B PXN RAB14 STK39 TNIK TOM1L1 TRIM32 VASP VCL VDAC1
Entrez ID		51552	2934
HPRD ID		06693	00674
Ensembl ID		ENSG00000119396	ENSG00000148180
Uniprot IDs		A0A024R845 P61106	A0A0A0MS51 A0A0A0MT01 A0A384MEF1 B7Z4U6 P06396
PDB IDs		1Z0F 4D0G 4DRZ	1C0F 1C0G 1D4X 1DEJ 1EQY 1ESV 1H1V 1KCQ 1MDU 1NLV 1NM1 1NMD 1P8X 1P8Z 1SOL 1T44 1YAG 1YVN 2FF3 2FF6 2FH1 2FH2 2FH3 2FH4 3A5L 3A5M 3A5N 3A5O 3CI5 3CIP 3CJB 3CJC 3FFK 3FFN 3TU5 4PKG 4PKH 4PKI 4S10 4Z94 5DD2 5FAE 5FAF 5H3M 5H3N 5O2Z 5UBO 5ZZ0 6H1F 6JCO 6JEG 6JEH 6LJE 6LJF 6Q9R 6Q9Z 6QBF 6QW3
Enriched GO Terms of Interacting Partners?
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