IL27RA and IL27

Number of citations of the paper that reports this interaction (PubMedID 12121660)
437

Data Source:
HPRD (in vitro, in vivo)

		IL27RA	IL27
Description		interleukin 27 receptor subunit alpha	interleukin 27
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Cytosol
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity	Signaling Receptor Binding Cytokine Activity Protein Binding Interleukin-27 Receptor Binding
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Positive Regulation Of Defense Response To Virus By Host Inflammatory Response Signal Transduction Response To Bacterium Positive Regulation Of Interferon-gamma Production Regulation Of T Cell Proliferation Innate Immune Response Regulation Of T-helper 1 Cell Differentiation
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Interleukin-27 signaling Interleukin-27 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Ankylosing spondylitis ( 23749187) Blood protein levels ( 29875488) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body mass index ( 28892062 29273807) Brain morphology (MOSTest) ( 32665545) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronic obstructive pulmonary disease ( 28166215) Crohn's disease ( 30500874 28067908 21102463 32581322) Extremely high intelligence ( 29520040) FEV1 ( 30804560) General cognitive ability ( 29844566) Household income (MTAG) ( 31844048) Inflammatory bowel disease ( 28067908 23128233) Inflammatory bowel disease (early onset) ( 19915574) Intelligence (MTAG) ( 29326435) Lamb consumption ( 32066663) Lung function (FVC) ( 30804560) Mean corpuscular hemoglobin concentration ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Plateletcrit ( 32888494) Red cell distribution width ( 32888494) Type 1 diabetes ( 21829393 25751624 19430480)
Interacting Genes		13 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6	1 interacting genes: IL27RA
Entrez ID		9466	246778
HPRD ID		09247	16307
Ensembl ID		ENSG00000104998	ENSG00000197272
Uniprot IDs		Q6UWB1	Q8NEV9
PDB IDs
Enriched GO Terms of Interacting Partners?
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