IL27RA and DEFB121

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		IL27RA	DEFB121
Description		interleukin 27 receptor subunit alpha	defensin beta 121
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Interleukin-12 Receptor Complex Receptor Complex Interleukin-23 Receptor Complex	Extracellular Region
	Molecular Function	Transmembrane Signaling Receptor Activity Cytokine Receptor Activity Interleukin-12 Receptor Binding Protein Binding Cytokine Binding Interleukin-23 Binding Interleukin-27 Receptor Activity	Molecular_function Protein Binding
	Biological Process	Positive Regulation Of T-helper 1 Type Immune Response Negative Regulation Of Type 2 Immune Response Immune Response Cell Surface Receptor Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Activated T Cell Proliferation Regulation Of Isotype Switching To IgG Isotypes Defense Response To Gram-positive Bacterium Interleukin-27-mediated Signaling Pathway Negative Regulation Of T-helper 17 Type Immune Response Negative Regulation Of T Cell Extravasation	Defense Response To Bacterium Innate Immune Response
Pathways		Interleukin-35 Signalling Interleukin-27 signaling Interleukin-27 signaling	Beta defensins Defensins
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Immune response to measles-mumps-rubella vaccine ( 24811271) Lymphocyte counts ( 32888494) Lymphocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Prudent dietary pattern ( 28644415)
Interacting Genes		13 interacting genes: BRICD5 CLDN2 DEFB121 DERL3 EBI3 GALNT15 GDF15 IL27 MAPK8 MFSD5 SLC41A2 STAT1 YIPF6	10 interacting genes: CD40 CLEC2D FAM209A GJA8 IL27RA LAYN LRRC25 NECTIN4 SSMEM1 SYNE4
Entrez ID		9466	245934
HPRD ID		09247	16791
Ensembl ID		ENSG00000104998	ENSG00000204548
Uniprot IDs		Q6UWB1	A0A384MDM0 Q5GRF9 Q5J5C9
PDB IDs
Enriched GO Terms of Interacting Partners?
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