ORMDL1 and KCNK4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ORMDL1	KCNK4
Description		ORMDL sphingolipid biosynthesis regulator 1	potassium two pore domain channel subfamily K member 4
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane SPOTS Complex	Plasma Membrane Integral Component Of Plasma Membrane Potassium Channel Complex
	Molecular Function	Protein Binding	Voltage-gated Ion Channel Activity Potassium Channel Activity Potassium Ion Leak Channel Activity Temperature-gated Cation Channel Activity Mechanosensitived Potassium Channel Activity
	Biological Process	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process	Potassium Ion Transport Memory Sensory Perception Of Pain Stabilization Of Membrane Potential Regulation Of Ion Transmembrane Transport Sensory Perception Of Temperature Stimulus Detection Of Mechanical Stimulus Involved In Sensory Perception Of Touch Cellular Response To Mechanical Stimulus Cellular Response To Fatty Acid Cellular Response To Alkaline PH Cellular Response To Temperature Stimulus Potassium Ion Transmembrane Transport
Pathways		Sphingolipid de novo biosynthesis	TWIK related potassium channel (TREK) Phase 4 - resting membrane potential
Drugs
Diseases
GWAS		Bilirubin levels ( 20639394) Ferritin levels ( 25162662)	Crohn's disease ( 28067908) Sarcoidosis ( 22837380) Vitiligo ( 27723757)
Interacting Genes		37 interacting genes: APP AQP6 ARL13B ASGR2 COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 GPR152 HSD17B11 KCNK4 LMNA LNX1 MFSD14B PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35C2 STOM TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27	4 interacting genes: DIDO1 NRG1 ORMDL1 RPL14
Entrez ID		94101	50801
HPRD ID		15092	12037
Ensembl ID		ENSG00000128699	ENSG00000182450
Uniprot IDs		Q9P0S3	A0A024R5C7 Q2YDA1 Q9NYG8
PDB IDs			3UM7 4I9W 4RUE 4RUF 4WFE 4WFF 4WFG 4WFH
Enriched GO Terms of Interacting Partners?
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