CD22 and AP2M1

Number of citations of the paper that reports this interaction (PubMedID 12646615)
18

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		CD22	AP2M1
Description		CD22 molecule	adaptor related protein complex 2 subunit mu 1
Image
GO Annotations	Cellular Component	Cytoplasm Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Neuronal Cell Body Membrane Recycling Endosome Extracellular Exosome	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse
	Molecular Function	IgM Binding Signaling Receptor Binding Protein Binding Protein Phosphatase Binding Carbohydrate Binding Sialic Acid Binding CD4 Receptor Binding	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding
	Biological Process	Negative Regulation Of Immunoglobulin Production Cell Adhesion Regulation Of Endocytosis Regulation Of B Cell Proliferation B Cell Activation Regulation Of Immune Response Negative Regulation Of Calcium-mediated Signaling Negative Regulation Of B Cell Receptor Signaling Pathway	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Vesicle-mediated Transport Receptor Internalization Cellular Protein-containing Complex Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs		Epratuzumab Inotuzumab ozogamicin Moxetumomab Pasudotox
Diseases
GWAS		Red cell distribution width ( 32888494)	Major depressive disorder ( 22472876)
Interacting Genes		20 interacting genes: ANKRD46 AP2M1 ATP2B4 CD19 GRB2 HP IGHM INPP5D LCP2 LYN MTDH NTAQ1 PIK3R1 PLCG1 PTPN6 PTPRC SHC1 ST6GAL1 SYK TMEM140	87 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD3D CDK11B CKS1B CORO7 CRIP1 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DNAJB11 DPPA2 DVL2 EAF1 EHD2 EIF1AD EIF4G1 ETV5 FAM90A1 FGF12 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HTR6 IKZF1 IL1RAP JADE1 KCNJ11 KNOP1 LAMP1 LPP LTB4R2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TMA16 UBC UTP25 XPA ZBTB8A ZNF581
Entrez ID		933	1173
HPRD ID		00114	03014
Ensembl ID		ENSG00000012124	ENSG00000161203
Uniprot IDs		P20273 Q0EAF5	B4DNB9 E9PFW3 Q96CW1
PDB IDs		5VKJ 5VKM 5VL3	1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?
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