AP2M1 and LPP

		AP2M1	LPP
Description		adaptor related protein complex 2 subunit mu 1	LIM domain containing preferred translocation partner in lipoma
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Cytosol Plasma Membrane Clathrin-coated Pit AP-2 Adaptor Complex Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Cytoplasmic Vesicle Endolysosome Membrane Clathrin-coated Endocytic Vesicle Extracellular Exosome Presynapse Postsynapse Glutamatergic Synapse	Stress Fiber Nucleus Cytosol Plasma Membrane Focal Adhesion
	Molecular Function	Signal Sequence Binding Protein Binding Lipid Binding Clathrin Adaptor Activity Transmembrane Transporter Binding Low-density Lipoprotein Particle Receptor Binding Disordered Domain Specific Binding	Protein Binding Metal Ion Binding
	Biological Process	Positive Regulation Of Receptor Internalization Intracellular Protein Transport Endocytosis Vesicle Budding From Membrane Vesicle-mediated Transport Receptor Internalization Cellular Protein-containing Complex Assembly Synaptic Vesicle Endocytosis Clathrin-dependent Endocytosis Regulation Of Vesicle Size Postsynaptic Neurotransmitter Receptor Internalization Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Protein Localization To Plasma Membrane	Biological_process Cell-cell Adhesion
Pathways		Nef mediated downregulation of CD28 cell surface expression Nef Mediated CD4 Down-regulation Retrograde neurotrophin signalling Retrograde neurotrophin signalling Nef Mediated CD8 Down-regulation Gap junction degradation Formation of annular gap junctions MHC class II antigen presentation EPH-ephrin mediated repulsion of cells Recycling pathway of L1 Recycling pathway of L1 WNT5A-dependent internalization of FZD4 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis VLDLR internalisation and degradation LDL clearance Potential therapeutics for SARS
Drugs
Diseases
GWAS		Major depressive disorder ( 22472876)	Addison's disease ( 33574239) Adult body size ( 32376654) Allergic disease (asthma, hay fever and/or eczema) (age of onset) ( 32603359) Allergic disease (asthma, hay fever and/or eczema) (multivariate analysis) ( 32603359) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184 31361310) Allergic sensitization ( 30013184 23817571) Allergy ( 27182965) Alopecia areata ( 25608926) Asthma ( 31361310 31959851 30929738 34103634 27182965 32296059 31619474) Asthma (childhood onset) ( 31036433 30929738) Asthma onset (childhood vs adult) ( 30929738) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) B cell non-Hodgkin lymphoma ( 23749188) B-cell malignancies (chronic lymphocytic leukemia, Hodgkin lymphoma or multiple myeloma) (pleiotropy) ( 28112199) Basal cell carcinoma ( 31174203 33549134 27539887) Blood protein levels ( 29875488) Celiac disease ( 22057235 20190752 30572963 18311140) Chronic kidney disease ( 29124443) Chronic lymphocytic leukemia ( 28165464 26956414) Creatinine levels ( 29124443) Crohn's disease ( 28067908) Cutaneous squamous cell carcinoma ( 27424798) CV-A6-associated hand, foot, and mouth disease (severe vs mild) ( 32634583) Early spontaneous preterm birth ( 31477735) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Estimated glomerular filtration rate ( 29124443) Evening vs. morning chronotype (sMEQ score) ( 32579418) Follicular lymphoma ( 25279986) Glaucoma ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Graves' disease ( 22922229) Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales) ( 33208821) Hodgkin's lymphoma ( 29196614) IgE levels ( 22075330) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998 29785010 31959993 29235454) Itch intensity from mosquito bite ( 28199695) Keratinocyte cancer (MTAG) ( 31174203) Mean spheric corpuscular volume ( 32888494) Medication use (adrenergics, inhalants) ( 31015401) Medication use (thyroid preparations) ( 31015401) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Mortality in sepsis ( 27639821) Mosquito bite size ( 28199695) Multiple sclerosis ( 31604244 24076602) Neutrophil percentage of granulocytes ( 27863252) Nodular sclerosis Hodgkin lymphoma ( 29196614) Obesity-related traits ( 23251661) Platelet distribution width ( 32888494) Renal function-related traits (BUN) ( 22797727) Response to platinum-based chemotherapy (cisplatin) ( 21844884) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Squamous cell carcinoma ( 31174203) Sum eosinophil basophil counts ( 27863252) Systemic lupus erythematosus ( 27399966) Thyroid stimulating hormone levels ( 32769997) Triglyceride levels ( 32203549) Type 2 diabetes ( 24509480 30054458 30297969 25760438 28869590) Type 2 diabetes (young onset) and obesity ( 24465431) Visceral adipose tissue adjusted for BMI ( 22589738) Visceral adipose tissue/subcutaneous adipose tissue ratio ( 22589738) Vitiligo ( 22951725 20410501 27723757) White matter integrity (bipolar disorder risk interaction) ( 23218918)
Interacting Genes		87 interacting genes: ADRA1B AGTR1 AP2B1 AQP4 ARRB2 ATXN1L BDKRB2 C1orf35 CACNA1A CD22 CD3D CDK11B CKS1B CORO7 CRIP1 CSNK2B CTLA4 CXorf51A CXorf51B DAB2 DCX DNAJB11 DPPA2 DVL2 EAF1 EHD2 EIF1AD EIF4G1 ETV5 FAM90A1 FGF12 FURIN FXR2 GAK GRIN2A GRIN2B H2BC10 H2BC13 H2BC21 H2BC4 H2BC6 H2BC7 H2BC8 HEXIM2 HTR6 IKZF1 IL1RAP JADE1 KCNJ11 KNOP1 LAMP1 LPP LTB4R2 LY9 MAB21L3 MED4 MEGF10 MFAP1 MPP1 MTURN NAA11 NCOR2 NDRG1 NKAPD1 PRPF18 PRPF38A PRR13 PTS RALBP1 RNF111 RPL22 RPL38 RRP12 RSPH14 RUNDC3A SFRP4 STON2 SYNJ1 TASOR TBC1D5 TGOLN2 TMA16 UBC UTP25 XPA ZBTB8A ZNF581	9 interacting genes: ACTN1 AP2M1 ATP5MF ATRAID FXR1 MTNR1A SCRIB SHPRH VASP
Entrez ID		1173	4026
HPRD ID		03014	02828
Ensembl ID		ENSG00000161203	ENSG00000145012
Uniprot IDs		B4DNB9 E9PFW3 Q96CW1	B7Z871 B7Z8W0 B7ZLW0 Q93052
PDB IDs		1H6E 6BNT 6URI
Enriched GO Terms of Interacting Partners?
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