VAPA and TMEM229B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		VAPA	TMEM229B
Description		VAMP associated protein A	transmembrane protein 229B
Image			No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Bicellular Tight Junction Microtubule Cytoskeleton Integral Component Of Membrane Nuclear Membrane Vesicle Azurophil Granule Membrane Perinuclear Region Of Cytoplasm Endoplasmic Reticulum Exit Site	Integral Component Of Membrane
	Molecular Function	Protein Binding Microtubule Binding Protein Domain Specific Binding FFAT Motif Binding Cadherin Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Cell Death Neuron Projection Development Protein Folding In Endoplasmic Reticulum Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation By Host Of Viral Release From Host Cell Negative Regulation By Host Of Viral Genome Replication Positive Regulation By Host Of Viral Genome Replication Membrane Fusion Protein Localization To Endoplasmic Reticulum COPII-coated Vesicle Budding
Pathways		Sphingolipid de novo biosynthesis Neutrophil degranulation Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Drugs
Diseases
GWAS		Diverticular disease ( 30177863) FEV1 ( 30804560) Heel bone mineral density ( 30598549) Lung function (FEV1/FVC) ( 30804560) Metabolite levels ( 23823483) Peak expiratory flow ( 30804560) Pulmonary function (smoking interaction) ( 23284291)	Basophil percentage of white cells ( 32888494) Glomerular filtration rate in chronic kidney disease ( 26420894) Glycerophospholipid levels ( 26068415) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Obesity-related traits ( 23251661) Parkinson's disease ( 25064009 28892059) Refractive error ( 32231278) Schizophrenia, bipolar disorder or major depressive disorder x sex interaction (3df) ( 34099189) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352)
Interacting Genes		37 interacting genes: ADGRG7 ADRB2 APOD AQP6 CACNG1 CD79A CYB561 CYBRD1 EBAG9 EBP EGFR ERBB2 GKN1 HSD17B13 JAGN1 KCNB1 LEPROTL1 NSF OPRM1 OSBP PGRMC2 RETREG3 RMDN2 SCN3B SEC11C SIK1 SLC16A7 SLC35B1 TMEM229B TMEM35A TMEM86B TMIE TMX2 USP20 VAMP1 VAMP2 ZBTB22	42 interacting genes: ACBD5 AQP6 ARL13B BIK CD53 CD79A CPLX4 CREB3L1 EBP ERGIC3 FAM209A FKBP7 GORAB GPX8 HSD17B13 ITGAM LHFPL5 MFF MFSD14B MGST3 MMGT1 MUC1 MYG1 NCR1 NEMP1 PANX1 PIGP PKMYT1 PVR REEP4 SEC22B SLC10A6 SLC39A2 SYT2 TLCD4 TMEM14B TMEM35A TMEM45B TMPRSS2 TSNARE1 VAPA VSIR
Entrez ID		9218	161145
HPRD ID		09299	08157
Ensembl ID		ENSG00000101558	ENSG00000198133
Uniprot IDs		Q9P0L0	A0A024R699 Q8NBD8
PDB IDs		2RR3 6TQR
Enriched GO Terms of Interacting Partners?
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